Bas van Hoeve

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TAR-DNA-binding protein-43 (TDP-43) is a nuclear protein that is thought to play a regulatory role in gene expression. Ubiquitinated TDP-43 is found in cytoplasmic inclusions in motor neuron disease (MND), frontotemporal lobar degeneration (FTLD-TDP), and MND with FTLD [4]. This shared histopathological hallmark led to the classiWcation of a new class of(More)
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