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BACKGROUND Bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor, may have activity in recurrent malignant gliomas. At recurrence some patients appear to develop nonenhancing infiltrating disease rather than enhancing tumor. METHODS We retrospectively reviewed 55 consecutive patients with recurrent malignant gliomas who(More)
STUDY OBJECTIVES To assess the accuracy of an automated system (Morpheus I Sleep Scoring System) for analyzing and quantifying polysomnographic data from a population with sleep-disordered breathing. SETTING Sleep laboratory affiliated with a tertiary care academic medical center. MEASUREMENTS AND RESULTS 31 diagnostic polysomnograms were blindly(More)
Lhermitte-Duclos disease (LDD) is a disorder sometimes referred to as a dysplastic gangliocytoma of the cerebellum. This is a focally indolent growth of the cerebellar cortex in which the folia enlarge due to a profusion of dysplastic cortical neurons and a thickening of the molecular layer. Loss of Purkinje cells and thinning of medullary white matter(More)
OBJECTIVE The aim of this study was to see if the training provided for Basic Surgical Trainees (BST's) by one consultant vascular surgeon has changed over a 15-year period. METHOD From a computerized database we have a 15-year record of varicose vein operations identifying the first and second surgeon. We have analysed cases involving the BST and those(More)
1523 Background: : The RECIST criteria (1D measurement) is widely used to measure response in solid tumors but there are few studies validating this criteria in brain tumors. In a small study in childhood brain tumors, Warren et al. (JNCI 2001;92:205) found a high concordance between 1D, 2D and 3D measurements in detecting partial responses but not disease(More)
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