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Arteries of several species, including man, tend to adjust their diameters such that the mean wall shear stress is in the range of 10-20 dynes cm-2. Additionally, intimal thickening in the human carotid bifurcation correlates well with the reciprocal of wall shear stress as determined in model studies. The correlation indicates that wherever the local mean(More)
Flow in a bifurcating tube system typifying a major bronchial bifurcation is studied experimentally with a two color, two velocity component laser Doppler anemometer. The flow loop is composed of a pumping station, flow stratifiers and a constant head pressure tank; it can accommodate steady, pulsatile or oscillatory flow. The test section is a symmetric(More)
BACKGROUND AND PURPOSE The potential for successful treatment of intracranial aneurysms by flow diversion is gradually being recognized in the clinical setting; however, the devices currently available (stents) are not designed for flow diversion. We evaluate the long-term response of an appropriately designed flow diversion device in producing thrombotic(More)
Recent developments in minimally invasive approach to cerebrovascular diseases include the placement of stents in arteries for treatment of aneurysms. Preliminary clinical observations and experimental studies have shown that intravascular stents traversing the orifice may lead to thrombosis and subsequent occlusion of the aneurysm. The alterations in(More)
We investigated the changes of flow patterns in a blood vessel with a side wall aneurysm resulting from placement of a stent. Local hemodynamics can be markedly altered by placing an intravascular stent, which covers the orifice of the aneurysm. The alternations in flow patterns can lead to flow stasis in the aneurysmal pouch and promote the formation of a(More)
PURPOSE To evaluate the hemodynamics and tissue response associated with stent placement in low-flow-velocity arteries. METHODS Six self-expanding nitinol stents (5.5 mm caliber) were implanted transfemorally within the proximal segments of vertebral arteries (2.5 mm diameter) in six adult dogs during anticoagulative protection. RESULTS Control(More)
Endovascular stenting appears to be an appealing treatment modality to selected complex intracranial aneurysms. However, stents currently used for endovascular treatment are not specifically designed for the cerebrovasculature. Stent parameters, such as porosity and filament size, have to be carefully optimized for long-term successful treatment. We(More)
Aneurysmal recanalization and coil compaction after coil embolization of intracranial aneurysms are seen in as many as 40% of cases. Higher packing density has been suggested to reduce both coil compaction and recanalization. Basilar bifurcation aneurysms remain a challenge due possibly to the hemodynamics of this specific aneurysm/parent vessel(More)
OBJECTIVE One concern with respect to stent procedures performed to treat patients with intracranial lesions is the fate of normal major arterial branches after stents are placed across them. Because most of these lesions occur at vessel bifurcations or at branch points, a normal major branch often arises near the lesion and may be difficult to avoid during(More)