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BACKGROUND AND PURPOSE The potential for successful treatment of intracranial aneurysms by flow diversion is gradually being recognized in the clinical setting; however, the devices currently available (stents) are not designed for flow diversion. We evaluate the long-term response of an appropriately designed flow diversion device in producing thrombotic(More)
BACKGROUND AND PURPOSE The rete mirabile in swine has been proposed as an arteriovenous malformation (AVM) model for acute experimental studies through surgical creation of a large carotid-jugular fistula. This report describes two endovascular modifications to simplify the surgical creation and provides hemodynamic parameters for the AVM model. METHODS(More)
We investigated the changes of flow patterns in a blood vessel with a side wall aneurysm resulting from placement of a stent. Local hemodynamics can be markedly altered by placing an intravascular stent, which covers the orifice of the aneurysm. The alternations in flow patterns can lead to flow stasis in the aneurysmal pouch and promote the formation of a(More)
It has been known for more than a decade that intracranial aneurysms can be successfully treated by deploying a porous meshed tube in the parent vessel of the aneurysm. Such devices are currently called flow diverters because they promote intraneurysmal flow stasis and thrombosis by diverting blood flow away from the aneurysm sac. The objective of this(More)
PURPOSE To evaluate the hemodynamics and tissue response associated with stent placement in low-flow-velocity arteries. METHODS Six self-expanding nitinol stents (5.5 mm caliber) were implanted transfemorally within the proximal segments of vertebral arteries (2.5 mm diameter) in six adult dogs during anticoagulative protection. RESULTS Control(More)
The latest class of neuroendovascular devices being evaluated is intended to treat cerebral aneurysms. In addition to inducing flow stasis-mediated thrombosis of aneurysms and thus at times being referred to as flow diverters, these devices reconstitute pathologic arterial segments to near-physiologic normalcy. The successful implementation of such an(More)
BACKGROUND AND PURPOSE Liquid embolic agents are increasingly gaining importance in the embolization of cerebral arteriovenous malformations (AVMs). Currently, the most commonly used agent is N-butyl 2-cyanoacrylate (NBCA). Various NBCA mixtures, arterial hypotension, and Valsalva maneuver (increased positive end-expiratory pressure) during the injection of(More)
Recent developments in minimally invasive approach to cerebrovascular diseases include the placement of stents in arteries for treatment of aneurysms. Preliminary clinical observations and experimental studies have shown that intravascular stents traversing the orifice may lead to thrombosis and subsequent occlusion of the aneurysm. The alterations in(More)
Endovascular stenting of aneurysms offers potential advantages over surgical clipping. Stenting is minimally invasive, and with the implementation of rapidly developing micro and nano technologies, it will in the future be possible to deploy stents in more remote locations of the cerebrovasculature. The key advantage of stenting is that in addition to(More)