Bartosz Michalowski

Learn More
Recently, D.J. Hall et al. reported that ethidium (E(+)) is formed as a major product of hydroethidine (HE) or dihydroethidium reaction with superoxide (O2(-)) in intact animals with low tissue oxygen levels (J. Cereb. Blood Flow Metab. 32:23-32, 2012). The authors concluded that measurement of E(+) is an indicator of O2(-) formation in intact brains of(More)
Aromatic boronic acids react rapidly with peroxynitrite (ONOO(-)) to yield phenols as major products. This reaction was used to monitor ONOO(-) formation in cellular systems. Previously, we proposed that the reaction between ONOO(-) and arylboronates (PhB(OH)2) yields a phenolic product (major pathway) and a radical pair PhB(OH)2O(•-)···(•)NO2 (minor(More)
Over the last 40 years, there has been tremendous progress in understanding the biological reactions of reactive oxygen species (ROS) and reactive nitrogen species (RNS). It is widely accepted that the generation of ROS and RNS is involved in physiological and pathophysiological processes. To understand the role of ROS and RNS in a variety of pathologies,(More)
Coffee may exert a preventive effect on arterial thrombosis. Trigonelline is one of the most abundant compounds in coffee that undergoes pyrolysis upon roasting of coffee beans. The aim of the present study was to identify pyridinium compounds formed upon trigonelline pyrolysis and coffee roasting and to investigate the effect of three of them, i.e.,(More)
The way we interact with manipulable objects varies substantially depending on the goal of the intended action. Surprisingly, very little is known about the neural underpinnings of planning disparate actions and interactions taken with tools, e.g., whether or not the praxis representation network (PRN) of the left cerebral hemisphere is involved in each(More)
While neuroscientific and behavioral studies indicate that the intention to properly use, transmit, or displace a tool may engage different mechanisms in the brain, no study has directly compared activation patterns associated with the control of actions motivated by such distinct goals. Here, we used functional magnetic resonance imaging to establish the(More)
The testing of Convulsofin carried out in 220 patients at 14 clinics over a period of six months confirms the international experience gained with valproic acid and sodium valproinate. The main field of application of Convulsofin according to the experience gained will again be the treatment of fits in generalised primary epilepsy for which it permits to(More)
  • 1