Bart van Leeuwen

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Activating mutations of RAS frequently occur in subsets of human cancers, indicating that RAS activation is important for tumorigenesis. However, a large proportion of these cancers still retain wild-type RAS alleles, suggesting that either the RAS pathway is activated in a distinct manner or another pathway is deregulated. To uncover novel tumor-suppressor(More)
Tibial bones are shorter and less resistant to shear forces after treatment with doxorubicin, methotrexate, or cisplatin. We investigated the pattern of failure after shear loading of the proximal tibial growth plate in rats treated with these chemotherapeutic agents. Male Wistar rats from the age of 4 weeks were given doxorubicin intravenously at 15 mg/m2(More)
Bart van Leeuwen bart@netage.nl / @semanticfire Bart van Leeuwen combines his 15 years firefighting experience with 17 years of netage.nl ownership. This combination allows him to highlight a new perspective on operational information delivery. With the ever larger amount of available data and changes in tactical approaches to firefighting new and fresh(More)
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