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Viral infection triggers innate immune sensors to produce type I interferon. However, infection of T cells and macrophages with human immunodeficiency virus (HIV) does not trip those alarms. How HIV avoids activating nucleic acid sensors is unknown. Here we found that the cytosolic exonuclease TREX1 suppressed interferon triggered by HIV. In Trex1(-/-)(More)
Viral infection triggers innate immune sensors to produce type I interferons (IFN). However, HIV infection of T cells and macrophages does not trip these alarms. How HIV avoids activating nucleic acid sensors is unknown. The cytosolic exonuclease TREX1 suppressed IFN triggered by HIV. In Trex1 −/− mouse cells and human CD4 + T cells and macrophages in which(More)
1 Supplementary Figures and Tables Supplementary Fig. 1. siRNA suppression of TREX1, but not some other SET complex genes, increases IFN-β-Luc activity in response to HIV in 293T cells. (a) 293T cells were transfected with indicated siRNAs for 48 h, infected with HIV-GFP for 6 h, and co-transfected with IFN-β-Luc and CMV-Renilla-Luc plasmids for 20 h.(More)
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