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Transcatheter implantation of homologous "off-the-shelf" tissue-engineered heart valves with self-repair capacity: long-term functionality and rapid in vivo remodeling in sheep.
Off-the-shelf human decellularized tissue-engineered heart valves in a non-human primate model.
Computational modeling guides tissue-engineered heart valve design for long-term in vivo performance in a translational sheep model
The hypothesis that integration of a computationally inspired heart valve design into TE methodologies could guide tissue remodeling toward long-term functionality in tissue-engineered heart valves (TEHVs) is tested and suggests the relevance of an integrated in silico, in vitro, and in vivo bioengineering approach as a basis for the safe and efficient clinical translation of TEHVs.
Improved Geometry of Decellularized Tissue Engineered Heart Valves to Prevent Leaflet Retraction
- Bart Sanders, S. Loerakker, F. Baaijens
- Biology, EngineeringAnnals of Biomedical Engineering
- 17 July 2015
An improved DTEHV is proposed that is expected to be less prone to host cell mediated leaflet retraction and will remain competent after implantation by using a constraining bioreactor insert during culture.
In vitro fabrication of autologous living tissue‐engineered vascular grafts based on prenatally harvested ovine amniotic fluid‐derived stem cells
- B. Weber, Debora Kehl, S. Hoerstrup
- Biology, EngineeringJournal of tissue engineering and regenerative…
- 1 January 2016
The isolation and use of autologous ovine AFCs as cell source for cardiovascular tissue engineering applications are investigated, laying the foundation for the use of this relevant pre‐clinical in vivo assessment model for future amniotic fluid cell‐based therapeutic applications.
Computationally Designed 3D Printed Self-Expandable Polymer Stents with Biodegradation Capacity for Minimally Invasive Heart Valve Implantation: A Proof-of-Concept Study
- M. S. Cabrera, Bart Sanders, O. J. G. M. Goor, A. Driessen-Mol, C. Oomens, F. Baaijens
- Engineering, Medicine3D printing and additive manufacturing
- 1 March 2017
This proof-of-concept study demonstrates the design and manufacture of a polymer stent with a mechanical performance comparable to that of conventional nitinol stents used for heart valve implantation in animal trials.
Adipose derived tissue engineered heart valve
Human ADSCs represent a promising alternative autologous mesenchymal cell source for TEHVs that is of large clinical relevance due to their easy accessibility, efficient proliferation and excellent tissue formation capacities.
First percutaneous implantation of a completely tissue-engineered self-expanding pulmonary heart valve prosthesis using a newly developed delivery system: a feasibility study in sheep
- H. Spriestersbach, Antonia Prudlo, B. Schmitt
- Medicine, EngineeringCardiovascular Intervention and Therapeutics
It was demonstrated that completely in vitro tissue-engineered heart valves are thin and stable enough to be crimped and implanted transvenously into pulmonary position.
In Vivo Collagen Remodeling in the Vascular Wall of Decellularized Stented Tissue-Engineered Heart Valves.
- S. Ghazanfari, A. Driessen-Mol, C. Bouten
- Biology, EngineeringTissue engineering. Part A
- 13 July 2015
The collagen matrix in the wall of decellularized TEHVs shows clear structural remodeling and maturation with time, and while collagen orientation rapidly remodels toward a native anisotropic architecture on the luminal side of the engineered valvular wall, it is dominated and guided by stent geometry on the outer side ofThe wall.
*The Effects of Scaffold Remnants in Decellularized Tissue-Engineered Cardiovascular Constructs on the Recruitment of Blood Cells
- Bart Sanders, A. Driessen-Mol, C. Bouten, F. Baaijens
- Biology, MedicineTissue engineering. Part A
- 1 October 2017
It is indicated that scaffold remnants can influence the immune response in DTEC, being responsible for rapid cell infiltration, and proinflammatory cytokines such as interleukin (IL)-1α, IL-6, and tumor necrosis factor alpha (TNFα) were significantly upregulated in the DTEC without scaffold remnant.