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Accuracy and precision of pseudo-continuous arterial spin labeling perfusion during baseline and hypercapnia: A head-to-head comparison with 15O H2O positron emission tomography

• D. F. R. Heijtel, Henri J. M. M. Mutsaerts, +11 authors Aart J. Nederveen
• NeuroImage
• 2014

Measurements of the cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) provide useful information about cerebrovascular condition and regional metabolism. Pseudo-continuous arterial spin… (More)

Image-derived input functions for PET brain studies

• Jurgen E. M. Mourik, Mark Lubberink, +4 authors Ronald Boellaard
• European Journal of Nuclear Medicine and…
• 2008

To assess the robustness of a previously introduced method to obtain accurate image-derived input functions (IDIF) for three other tracers. Dynamic PET and online blood data of five repeat [11C]PIB… (More)

Microglial activation in healthy aging

• Alie Schuitemaker, Ronald Boellaard, +8 authors Bart N. M. van Berckel
• NeuroImage
• 2010

Healthy brain aging is characterized by neuronal loss and decline of cognitive function. Neuronal loss is closely associated with microglial activation and postmortem studies have indeed suggested… (More)

Longitudinal imaging of Alzheimer pathology using [11C]PIB, [18F]FDDNP and [18F]FDG PET

• Rik Ossenkoppele, Nelleke Tolboom, +9 authors Bart N. M. van Berckel
• European Journal of Nuclear Medicine and…
• 2012

[11C]PIB and [18F]FDDNP are PET tracers for in vivo detection of the neuropathology underlying Alzheimer’s disease (AD). [18F]FDG is a glucose analogue and its uptake reflects metabolic activity. The… (More)

Image derived input functions for dynamic High Resolution Research Tomograph PET brain studies

• Jurgen E. M. Mourik, Floris H. P. van Velden, +4 authors Ronald Boellaard
• NeuroImage
• 2008

The High Resolution Research Tomograph (HRRT) is a dedicated human brain positron emission tomography (PET) scanner. The aim of the present study was to validate the use of image derived input… (More)

Modulation of Amphetamine-Induced Dopamine Release by Group II Metabotropic Glutamate Receptor Agonist LY354740 in Non-Human Primates Studied with Positron Emission Tomography

• Bart N. M. van Berckel, Lawrence S. Kegeles, +6 authors Marc Laruelle
• Neuropsychopharmacology
• 2006

Pharmacological evidence suggests that schizophrenia is associated with increased stimulation of dopamine (DA) D2 receptors. Recently, several groups have demonstrated that amphetamine-induced DA… (More)

Distinct perfusion patterns in Alzheimer’s disease, frontotemporal dementia and dementia with Lewy bodies

• Maja A. A. Binnewijzend, Joost P. A. Kuijer, +9 authors Frederik Barkhof
• European Radiology
• 2014

To compare pseudo-continuous arterial spin-labelled (PCASL) magnetic resonance imaging (MRI) measured quantitative cerebral blood flow (CBF) of patients with frontotemporal dementia (FTD), dementia… (More)

Simplified parametric methods for [11C]PIB studies

• Maqsood Yaqub, Nelleke Tolboom, +5 authors Adriaan A. Lammertsma
• NeuroImage
• 2008

The purpose of the present study was to evaluate the performance of various parametric reference tissue models for quantification of [11C]PIB studies. Several models with and without fixing the… (More)

Comparison of HRRT and HR+ Scanners for Quantitative (R)-[11C]verapamil, [11C]raclopride and [11C]flumazenil Brain Studies

• Floris H. P. van Velden, Syahir M. Mansor, +8 authors Marc C. Huisman
• Molecular Imaging and Biology
• 2014

This study was conducted to directly compare the high-resolution research tomograph (HRRT) (high-resolution brain) and HR+ (standard whole-body) positron emission tomography (PET) only scanners for… (More)

Further human evidence for striatal dopamine release induced by administration of ∆9-tetrahydrocannabinol (THC): selectivity to limbic striatum

• Matthijs G. Bossong, Mitul A. Mehta, Bart N. M. van Berckel, Oliver D. Howes, René S. Kahn, Paul R. A. Stokes
• Psychopharmacology
• 2015

Elevated dopamine function is thought to play a key role in both the rewarding effects of addictive drugs and the pathophysiology of schizophrenia. Accumulating epidemiological evidence indicates… (More)

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