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  • Sébastien S. Hébert, Katrien Horré, +6 authors Bart De Strooper
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 2008 (First Publication: 29 April 2008)
  • Although the role of APP and PSEN genes in genetic Alzheimer's disease (AD) cases is well established, fairly little is known about the molecular mechanisms affecting Aβ generation in sporadic AD.Continue Reading
  • Matias Simons, Patrick D. Keller, Bart De Strooper, Konrad Beyreuther, Carlos G Dotti, Keith Simons
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1998 (First Publication: 26 May 1998)
  • The amyloid precursor protein (APP) plays a crucial role in the pathogenesis of Alzheimer's disease. During intracellular transport APP undergoes a series of proteolytic cleavages that lead to theContinue Reading
  • Dieter Hartmann, Bart De Strooper, +8 authors Paul Saftig
  • Biology, Medicine
  • Human molecular genetics
  • 2002 (First Publication: 2 October 2002)
  • The metalloprotease ADAM 10 is an important APP alpha-secretase candidate, but in vivo proof of this is lacking. Furthermore, invertebrate models point towards a key role of the ADAM 10 orthologuesContinue Reading
  • Thorsten Maretzky, Karina Reiss, +6 authors Paul Saftig
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2005 (First Publication: 28 June 2005)
  • E-cadherin controls a wide array of cellular behaviors, including cell-cell adhesion, differentiation, and tissue development. We show here that E-cadherin is cleaved specifically by ADAM (aContinue Reading
  • An Herreman, Dieter Hartmann, +14 authors Bart De Strooper
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1999 (First Publication: 12 October 1999)
  • Mutations in the homologous presenilin 1 (PS1) and presenilin 2 (PS2) genes cause the most common and aggressive form of familial Alzheimer's disease. Although PS1 function and dysfunction have beenContinue Reading
  • Bruno Vincent, Erwan Paitel, +6 authors Frederic Checler
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2001 (First Publication: 12 October 2001)
  • We showed previously that PrPc undergoes constitutive and phorbol ester-regulated cleavage inside the 106-126 toxic domain of the protein, leading to the production of a fragment referred to as N1.Continue Reading
  • Osamu Nagano, Daizo Murakami, +6 authors Hideyuki Saya
  • Biology, Medicine
  • The Journal of cell biology
  • 2004 (First Publication: 21 June 2004)
  • CD44 is an adhesion molecule that interacts with hyaluronic acid (HA) and undergoes sequential proteolytic cleavages in its ectodomain and intramembranous domain. The ectodomain cleavage is triggeredContinue Reading