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Minocycline neuroprotects, reduces microgliosis, and inhibits caspase protease expression early after spinal cord injury.

• Barry W Festoff, Syed Ameenuddin, Paul M. Arnold, Andrea Wong, Karen S Santacruz, Bruce A Citron
• Journal of neurochemistry
• 2006

Minocycline, a clinically used tetracycline for over 40 years, crosses the blood-brain barrier and prevents caspase up-regulation. It reduces apoptosis in mouse models of Huntington's disease and… (More)

Xeroderma pigmentosum. An inherited diseases with sun sensitivity, multiple cutaneous neoplasms, and abnormal DNA repair.

• Jay H. Robbins, Kenneth H Kraemer, Marvin A. Lutzner, Barry W Festoff, H G Coon
• Annals of internal medicine
• 1974

Proteolytic action of thrombin is required for electrical activity-dependent synapse reduction.

• Ying Liu, R. Douglas Fields, Barry W Festoff, Phillip G. Nelson
• Proceedings of the National Academy of Sciences…
• 1994

Molecular mechanisms of activity-dependent synapse reduction were studied in an in vitro mammalian neuromuscular preparation. Synapse reduction in this model is activity-dependent and is… (More)

Participation of protease-activated receptor-1 in thrombin-induced microglial activation.

• Zhiming Suo, Min Wu, +5 authors Barry W Festoff
• Journal of neurochemistry
• 2002

Activation of microglia, the resident macrophages in the CNS, plays a significant role in neuronal death or degeneration in a broad spectrum of CNS disorders. Recent studies indicate that nanomolar… (More)

Thrombin perturbs neurite outgrowth and induces apoptotic cell death in enriched chick spinal motoneuron cultures through caspase activation.

• Victoria L. Turgeon, Eric W Lloyd, Siwei Wang, Barry W Festoff, Lucien J. Houenou
• The Journal of neuroscience : the official…
• 1998

Increasing evidence indicates several roles for thrombin-like serine proteases and their cognate inhibitors (serpins) in normal development and/or pathology of the nervous system. In addition to its… (More)

HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer’s disease

• Barry W Festoff, Ravi K Sajja, Patrick Van Dreden, Luca Cucullo
• Journal of Neuroinflammation
• 2016

The blood-brain barrier (BBB) dysfunction represents an early feature of Alzheimer’s disease (AD) that precedes the hallmarks of amyloid beta (amyloid β) plaque deposition and neuronal… (More)

Developmental Regulation of Amyloid Precursor Protein at the Neuromuscular Junction in Mouse Skeletal Muscle

• Mohammed Akaaboune, Bernadette Allinquant, +5 authors Daniel Hantaï
• Molecular and Cellular Neuroscience
• 2000

Amyloid precursor protein (APP), associated with Alzheimer's disease plaques, is known to be present in synapses of the brain and in the adult neuromuscular junction (NMJ). In the present study we… (More)

Mitochondrial lysates induce inflammation and Alzheimer's disease-relevant changes in microglial and neuronal cells.

• Heather M Wilkins, Steven M. Carl, +4 authors Russell Howard Swerdlow
• Journal of Alzheimer's disease : JAD
• 2015

Neuroinflammation occurs in Alzheimer's disease (AD). While AD genetic studies implicate inflammation-relevant genes and fibrillar amyloid-β protein promotes inflammation, our understanding of AD… (More)

Rapid tau aggregation and delayed hippocampal neuronal death induced by persistent thrombin signaling.

• Zhiming Suo, Min Wu, Bruce A Citron, Robert E. Palazzo, Barry W Festoff
• The Journal of biological chemistry
• 2003

Tau hyperphosphorylation, leading to self-aggregation, is widely held to underlie the neurofibrillary degeneration found in Alzheimer's disease (AD) and other tauopathies. However, it is unclear… (More)

A molecular mechanism for synapse elimination: novel inhibition of locally generated thrombin delays synapse loss in neonatal mouse muscle.

• Mikhail N. Zoubine, Jennifer S. Y. Ma, Irina V. Smirnova, Bruce A Citron, Barry W Festoff
• Developmental biology
• 1996

Activity-dependent, polyneuronal synapse elimination (ADPSE) is a programmed, regressive event in the development of the nervous system and readily studied at the neuromuscular junction, where it is… (More)

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