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Journals and Conferences
The control of respiratory tract infections in cystic fibrosis has for many years utilized a wide range of antibiotics. The effect of administering one or more antibiotics to combat an invading organism has, as might be expected, been variable. We have attempted here to determine some of the factors that are responsible for these variations in the hope that… (More)
Cystic fibrosis (CF), transmitted by a single autosomal recessive gene, affects 1 in 2500 of the population. A biochemical abnormality affects the quality of mucus, and results in pancreatic duct obstruction, and progressive lung damage as a result of respiratory infection. Thirty years ago it is probable that almost all affected babies died of pneumonia in… (More)
The attraction of bacteria commonly found in the respiratory tract in cystic fibrosis to glycoprotein at pH 7 has been studied. The effect of washing on the removal of bacteria from the glycoprotein has also been investigated, and the value of doing both washed and unwashed sputum cultures is discussed.
One of the main criteria for the diagnosis of cystic fibrosis of the pancreas is the presence of a raised sweat sodium level in the patient (Di Sant' Agnese, Darling, Perera, and Shea, 1953). The standard method of using pilocarpine iontophoresis to produce sweat (Gibson and Cooke, 1959), and estimating the sodium present by conductivity or flame… (More)
A study has been made on the penetration values in vitro of antibiotics through hog gastric mucin at pH 7.4. Determinations have also been done on the binding of antibiotics to mucus and human plasma. The mucolytic agent N-acetyl cysteine has been studied in regard to its effect on antibiotics penetrating mucus and for any possible inactivation of… (More)
The prognosis of cystic fibrosis depends very largely upon the earliest possible diagnosis, and the institution of a careful regime of management, including physiotherapy, pancreatin replacement, and antibiotics, before lung damage has been caused by respiratory obstruction and infection. The ideal method of doing this would be by a screening test in early… (More)
The differential attraction in vitro of antibiotics to blood lymphocytes and salivary glycoprotein was studied in an attempt to determine the distribution of antibiotics in sputum. Results from studies in vivo on sputum antibiotic levels are also presented.