Barry P Sleckman

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Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.

Susanne J. Szabo, Brandon M. Sullivan, Claudia Stemmann, Abhay R Satoskar, Barry P Sleckman, L. H. Glimcher
Science
2002

T-bet is a member of the T-box family of transcription factors that appears to regulate lineage commitment in CD4 T helper (TH) lymphocytes in part by activating the hallmark TH1 cytokine,… (More)

ATM stabilizes DNA double-strand-break complexes during V(D)J recombination

Andrea L. Bredemeyer, Girdhar G Sharma, +8 authors Barry P Sleckman
Nature
2006

The ATM (ataxia-telangiectasia mutated) protein kinase mediates early cellular responses to DNA double-strand breaks (DSBs) generated during metabolic processes or by DNA-damaging agents. ATM… (More)

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

Ken Cadwell, John Y S Liu, +15 authors Herbert W. Virgin Iv
Nature
2008

Susceptibility to Crohn’s disease, a complex inflammatory disease involving the small intestine, is controlled by over 30 loci. One Crohn’s disease risk allele is in ATG16L1, a gene homologous to the… (More)

H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.

Beth A. Helmink, Anthony T. Tubbs, +8 authors Barry P Sleckman
Nature
2011

DNA double-strand breaks (DSBs) are generated by the recombination activating gene (RAG) endonuclease in all developing lymphocytes as they assemble antigen receptor genes. DNA cleavage by RAG occurs… (More)

MYC is essential for the formation and maintenance of germinal centers

Dinis Pedro Calado, Yoshiteru Sasaki, +7 authors K. Rajewsky
Nature Immunology
2012

Germinal centers (GCs) are sites of intense B cell proliferation and are central for T cell–dependent antibody responses. However, the role of c-Myc, a key cell-cycle regulator, in this process has… (More)

Addendum: RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci

Susannah L. Hewitt, Bu Yin, +13 authors Jane A. Skok
Nature Immunology
2010

Susannah L Hewitt, Bu Yin, Yanhong Ji, Julie Chaumeil, Katarzyna Marszalek, Jeannette Tenthorey, Giorgia Salvagiotto, Natalie Steinel, Laura B Ramsey, Jacques Ghysdael, Michael A Farrar, Barry P… (More)

53BP1 facilitates long-range DNA end-joining during V(D)J recombination

Simone Difilippantonio, Eric J. Gapud, +8 authors André Nussenzweig
Nature
2008

Variable, diversity and joining (V(D)J) recombination and class-switch recombination use overlapping but distinct non-homologous end joining pathways to repair DNA double-strand-break intermediates.… (More)

53BP1 Mediates Productive and Mutagenic DNA Repair through Distinct Phosphoprotein Interactions

Elsa Callén, Michela Di Virgilio, +17 authors André Nussenzweig
Cell
2013

The DNA damage response (DDR) protein 53BP1 protects DNA ends from excessive resection in G1, and thereby favors repair by nonhomologous end-joining (NHEJ) as opposed to homologous recombination… (More)

Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements.

Barry P Sleckman, Judith Gorman, Frederick W Alt
Annual review of immunology
1996

Antigen receptor variable region genes are assembled from germline variable (V), diversity (D), and joining (J) gene segments. This process requires expression of V(D)J recombinase activity, and… (More)

DNA double strand breaks activate a multi-functional genetic program in developing lymphocytes

Andrea L. Bredemeyer, Beth A. Helmink, +14 authors Barry P Sleckman
Nature
2008

DNA double-strand breaks are generated by genotoxic agents and by cellular endonucleases as intermediates of several important physiological processes. The cellular response to genotoxic DNA breaks… (More)

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