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Characterization of the Early Events in Dengue Virus Cell Entry by Biochemical Assays and Single-Virus Tracking
TLDR
It was observed that DENV binds very inefficiently to the cells used, explaining at least in part the high infectious unit-to-particle ratio. Expand
Antiviral activity of human lactoferrin: inhibition of alphavirus interaction with heparan sulfate.
TLDR
It is concluded that human lactoferrin inhibits viral infection by interfering with virus-receptor interaction rather than by affecting subsequent steps in the viral cell entry or replication processes. Expand
Induction of cytotoxic T lymphocyte activity by immunization with recombinant Semliki Forest virus: indications for cross-priming.
TLDR
It is hypothesize that antigen presentation after SFV-based immunization proceeds via a mechanism in which APCs are not transfected directly but acquire antigen from other transfecting cells and present it to CTLs in a process of cross-priming. Expand
Behavior of a photoactivatable analog of cholesterol, 6‐photocholesterol, in model membranes
TLDR
The ability of this probe, under conditions in which it is not photoactivated to a carbene, to substitute for cholesterol in two unrelated assays is analyzed, suggesting that this analog is a suitable photoprobe of cholesterol. Expand
Sphingolipid and Cholesterol Dependence of Alphavirus Membrane Fusion
TLDR
It is suggested that SFV and SIN do not require the presence of lipid rafts for fusion with target membranes, and it is not necessary for sphingolipids to reside in a detergent-insoluble complex with cholesterol to promote SFV or SIN fusion. Expand
Adaptation of Alphaviruses to Heparan Sulfate: Interaction of Sindbis and Semliki Forest Viruses with Liposomes Containing Lipid-Conjugated Heparin
TLDR
A liposomal model system involving target liposomes containing lipid-conjugated heparin (HepPE) as an HS receptor analog for the virus may serve as a novel tool for the study of receptor interactions and membrane fusion properties of HS-interacting enveloped viruses. Expand
Liposomes as target membranes in the study of virus receptor interaction and membrane fusion.
TLDR
The liposomal model system involving lipid-conjugated heparin, described in this chapter, provides a useful tool for the study of virus-receptor interactions and viral membrane fusion processes. Expand
Reversible Acid-Induced Inactivation of the Membrane Fusion Protein of Semliki Forest Virus
TLDR
It is concluded that the SFV E1 fusion protein, after acid-induced dissociation from E2, rapidly adopts an intermediate, nontrimeric conformation in which it is no longer able to interact with target membrane lipids. Expand
Vertebrate Animals Used for Experimental and Other Scientific Purposes: Principles and Practice for Legislation and Protection
TLDR
This chapter is guiding the reader through the background of legislation and the principles behind laboratory animal science and legislation to create awareness and a basic level of knowledge in this field. Expand
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