Barry J Gray

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OBJECTIVE To evaluate the effects of an early community based pulmonary rehabilitation programme after hospitalisation for acute exacerbations of chronic obstructive pulmonary disease (COPD). DESIGN A single centre, randomised controlled trial. SETTING An inner city, secondary and tertiary care hospital in London. PARTICIPANTS 42 patients admitted(More)
Case 1 A 25-year-old nurse presented in September 1977 with a four-week history of sustained pyrexia, rigors, anorexia, weight loss, non-productive cough, and pleuritic chest pain. Since the age of 16 she had noticed transient mild wheeziness, associated with hay fever during the summer months. Wheezing had become episodic and more severe during her present(More)
The cough reflex has been investigated in insulin dependent diabetic patients with and without autonomic neuropathy. The cough response to inhaled citric acid was determined in eight patients with diabetes who had severe autonomic neuropathy and compared with that in 10 who had no evidence of neuropathy. The patients with autonomic neuropathy had a higher(More)
Induction of steroid metabolism has been reported after rifampicin administration but it is not known how much corticosteroid requirements increase and whether disease control can be satisfactorily maintained with increases in corticosteroid dosage. Because rifampicin may be needed in the treatment of tuberculosis in patients with steroid-dependent asthma,(More)
Theophylline pharmacokinetics were studied before and after rifampicin administration (600 mg daily for 1 wk). Rifampicin reduced the area under the concentration-time curve by 18% after the oral administration of sustained release aminophylline (450 mg) to 7 normal subjects (p less than 0.05) and increased the metabolic clearance and volume of distribution(More)
Transcutaneous oxygen tension (tcPO2) has been compared with arterial oxygen tension (PaO2 in 14 haemodynamically stable patients in an intensive care unit. Two calibration methods have been compared: (1) "In vitro" calibration, a two point calibration procedure carried out before attachment to the skin. (2) "In vivo" calibration, calibration using a single(More)
We have investigated possible mechanisms of response to airway cooling by studying the effects of sodium cromoglycate and ipratropium bromide on the changes in airways resistance that followed eucapnic hyperventilation with subfreezing air in a group of 12 patients with mild asthma and 10 normal subjects. We have also studied the period of refractoriness to(More)
To investigate the role of neural pathways in the nonasthmatic response to eucapnic hyperventilation with below freezing air five diabetic patients with severe symptomatic autonomic neuropathy were studied. Their responses were compared with those shown by five diabetic patients without autonomic neuropathy and five non-diabetic controls. After bronchial(More)
Continuous measurements of transcutaneous oxygen tension (tcPO2) were made in 23 patients with radiological evidence of emphysema, at rest and during a maximal progressive exercise test. tcPO2 during the final phase of exercise was compared with tcPO2 at rest; the mean change (exercising minus resting value) in tcPO2 (delta tcPO2) was -0.8 mm Hg (SD 10.5,(More)
Transcutaneous PO2 (tcPO2) and arterial PO2 (PaO2) were compared during exercise in six patients with pulmonary emphysema. For calibration purposes, the tcPO2 electrode was first attached to the skin and after stabilisation its reading was adjusted to correspond to the PO2 of an initial arterial blood sample. It was shown that tcPO2 measurement could follow(More)