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I n the fall of 2002, the Ecological Society of America (ESA) established a committee to develop an action plan for bolstering the research capabilities and impact of the ecological sciences. After much work and with substantial input from many people within and beyond the Society, the committee delivered a report to the ESA Governing Board in April 2004.(More)
DNA glycosylases that remove alkylated and deaminated purine nucleobases are essential DNA repair enzymes that protect the genome, and at the same time confound cancer alkylation therapy, by excising cytotoxic N3-methyladenine bases formed by DNA-targeting anticancer compounds. The basis for glycosylase specificity towards N3- and N7-alkylpurines is(More)
One aspect of producing secure operating systems involves the confinement of programs. This paper discusses the program confinement problem as addressed by the developers of a retrofitted version of the IBM VM/370 virtual machine monitor. This version of the system (called KVM/370) uses a security-kernel architecture to provide a provably secure multi-level(More)
W ithin the next 50 to 100 years, support and maintenance of an extended human family of 8 to 11 billion people will become difficult at best. Our consumption rates already exceed the supply of many resources crucial to human health, and few places on Earth do not bear the stamp of human impacts (1, 2). Fossil fuel combustion and fertilizer production have(More)
Executive Summary Environmental issues will define the 21st Century, as will a world with a large human population and ecosystems that are increasingly shaped by human intervention. The science of ecology can and should play a greatly expanded role in ensuring a future in which natural systems and the humans they include coexist on a more sustainable(More)
PURPOSE Defining the cytotoxicity of individual adducts in DNA is necessary for mechanistic understanding of human brain tumor resistance to therapeutic alkylating agents and for design of DNA repair-related antiresistance strategies. Our purpose is to characterize the sensitivity of human glioma cells to methyl-lexitropsin (Me-lex), a sequence-specific(More)
Policies are arising around the world, most recently in the United States, that mandate the implementation of marine spatial planning as a practical pathway towards ecosystem-based management. In the new United States ocean policy, and several other cases around the globe, ecosystem services are at the core of marine spatial planning, but there is little(More)
The oxidation of DNA resulting from reactive oxygen species generated during aerobic respiration is a major cause of genetic damage that, if not repaired, can lead to mutations and potentially an increase in the incidence of cancer and aging. A major oxidation product generated in cells is 8-oxoguanine (oxoG), which is removed from the nucleotide pool by(More)
We report on the physicochemical effects resulting from incorporating a 5-(3-aminopropyl) side chain onto a 2'-deoxyuridine (dU) residue in a short DNA hairpin. A combination of spectroscopy, calorimetry, density and ultrasound techniques were used to investigate both the helix-coil transition of a set of hairpins with the following sequence:(More)
In the present study, we have investigated the influence of telomerase inhibition in chemosensitivity of melanoma cells to temozolomide (TMZ), a methylating agent with promising antitumor activity against metastatic melanoma. In fact, telomerase, a ribonucleoprotein enzyme expressed in the majority of tumors, is presently considered an attractive target for(More)