Barry C. Moore

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One of the most important features of the auditory system is its action as a frequency analyser. The frequency analysis appears to have its basis in the mechanical patterns of vibration on the basilar membrane (BM). Its properties can be measured psychophysically using masking experiments and the results explained using the concept of the auditory filter(More)
Current literature describes several methods for the design of efficient siRNAs with 19 perfectly matched base pairs and 2 nt overhangs. Using four independent databases totaling 3336 experimentally verified siRNAs, we compared how well several of these methods predict siRNA cleavage efficiency. According to receiver operating characteristics (ROC) and(More)
The level of a masker necessary to mask a probe fixed in frequency and level was determined as a function of masker frequency using a two-interval forced-choice technique. Both simultaneous- and forward- masking techniques were used. Parameters investigated include the level of the probe tone and the frequency of the probe tone. The general form of the(More)
The venom peptides (i.e., conotoxins or conopeptides) that species in the genus Conus collectively produce are remarkably diverse, estimated to be around 50,000 to 140,000, but the pace of discovery and characterization of these peptides have been rather slow. To date, only a minor fraction have been identified and studied. However, the advent of(More)
The effect of loudness recruitment and threshold elevation together with reduced frequency selectivity have been simulated to examine the combined effect of the two major consequences of cochlear hearing loss on the intelligibility of speech in speech-shaped noise. In experiment 1, four conditions were simulated: a moderate flat loss with auditory filters(More)
This study examined the perceptual grouping of rapid tone sequences for listeners with normal hearing and listeners with unilateral and bilateral cochlear hearing loss. The sequence ABA-ABA- was used, where A and B represent sinusoidal tones bursts (10-ms rise/fall, 80-ms steady state, 20-ms interval between tones) and - represents a silent interval of 120(More)
Auditory-filter shapes at 2 kHz were estimated for 95 young normally hearing subjects using a notched-noise masker with spectrum level of 45 dB. Excluding two subjects with a recent history of noise exposure, the equivalent rectangular bandwidths (ERBs) of the filters were approximately normally distributed but the distribution had a slight positive skew.(More)
A bioinformatics approach to finding new cases of -1 frameshifting in the expression of human genes revealed a classical retrovirus-like heptanucleotide shift site followed by a potential structural stimulator in the paraneoplastic antigen Ma3 and Ma5 genes. Analysis of the sequence 3' of the shift site demonstrated that an RNA pseudoknot in Ma3 is(More)
Methods of measuring the frequency selectivity of the auditory system using masking techniques are outlined and described in terms of the concept of the auditory filter. The relationship between the auditory filter shape and excitation patterns is described. Evidence is reviewed showing that frequency selectivity is usually reduced in people with cochlear(More)