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Antagonistic interactions between adenosine A2a and dopamine D2 receptors and between adenosine A1 and dopamine D1 receptors have been previously found in the basal ganglia. Those interactions have been proposed to be key mechanisms of action responsible for the motor depressant effects of adenosine agonists and the motor activating effects of adenosine(More)
After Golgi-Cajal mapped neural circuits, the discovery and mapping of the central monoamine neurons opened up for a new understanding of interneuronal communication by indicating that another form of communication exists. For instance, it was found that dopamine may be released as a prolactin inhibitory factor from the median eminence, indicating an(More)
Recently evidence has been presented that adenosine A2A and dopamine D2 receptors form functional heteromeric receptor complexes as demonstrated in human neuroblastoma cells and mouse fibroblast Ltk- cells. These A2A/D2 heteromeric receptor complexes undergo coaggregation, cointernalization, and codesensitization on D2 or A2A receptor agonist treatments and(More)
Rat dorsal root ganglia (DRG) cells isolated and dissociated using standard procedures and then cryopreserved (non-purified), are available from Lonza. Batch tested, ready-to-use neonatal DRG cells have been proven to be ideal for in vitro study of axonal outgrowth, path finding, neuropathy, nerve re-growth, sensory receptor physiology and drug testing(More)
Ready-to-use, batch tested, cryopreserved dissociated neuronal cells combined with high quality, high-throughput adherent neuronal transfection of the 4D-Nucleofector™ Y Unit is an effective and time saving approach for researchers employing genetically modified strategies for their neurobiology programs. Cryopreserved primary neuronal cells dissociated(More)
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