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AI research in qualitative modeling makes possible new approaches to teaching people about science and technology. We are exploring the implications of this work for the design of intelligent learning environments. The domain of application is electrical circuits, but the approach can be generalized to other subjects. Our prototype instructional system is(More)
BACKGROUND We conducted a double-blind, randomized, placebo-controlled trial to determine the effects of oral cyclophosphamide on lung function and health-related symptoms in patients with evidence of active alveolitis and scleroderma-related interstitial lung disease. METHODS At 13 clinical centers throughout the United States, we enrolled 158 patients(More)
BACKGROUND Psoriasis is an immune-mediated disease characterized by aberrant epidermal differentiation, surface scale formation, and marked cutaneous inflammation. To better understand the pathogenesis of this disease and identify potential mediators, we used whole genome array analysis to profile paired lesional and nonlesional psoriatic skin and skin from(More)
One promising educational application of computers derives from their ability to dynamically simulate physical phenomena. Such systems permit students to explore, for instance, electrical circuit behavior or particle dynamics. In the past, these simulations have been based upon quantitative models. However, recent work in artificial intelligence has created(More)
We introduce a method for promoting reflective conversations during collaborative work which enables participants to explore their cognitive goals and processes and thereby develop a metacognitive understanding of their practice. This method, termed "cognitive facilitation," seeks to provide a conceptual and linguistic basis for metacognitive reflection by(More)
To identify potential pharmacodynamic biomarkers to guide dose selection in clinical trials using anti-interferon-alpha (IFN-α) monoclonal antibody (mAb) therapy for systemic lupus erythematosus (SLE), we used an Affymetrix human genome array platform and identified 110 IFN-α/β-inducible transcripts significantly upregulated in whole blood (WB) of 41 SLE(More)