Barbara Szomolay

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Bacterial biofilms demonstrate adaptive resistance in response to antimicrobial stress more effectively than corresponding planktonic populations. We propose here that, in biofilms, reaction-diffusion limited penetration may result in only low levels of antimicrobial exposure to deeper regions of the biofilm. Sheltered cells are then able to enter an(More)
Increasing susceptibility of the elderly to many infectious diseases is highly associated with the loss or delay in the generation of antigen-specific CD4(+) T cells. For Mycobacterium tuberculosis infection, where antigen-specific CD4(+) T cell derived IFN-gamma is essential, such a loss can lead to a significant failure to control infection. The present(More)
Phosphorylation-dephosphorylation cycles (PDCs) mediated by kinases and phosphatases are common in cellular signalling. Kinetic modelling of PDCs has shown that these systems can exhibit a variety of input-output (dose-response) behaviors including graded response, ultrasensitivity and bistability. In addition to proteins, there are a class of lipids known(More)
Bacterial biofilms demonstrate resistance in response to antimicrobial stress. This adaptive response is more effective than in the corresponding planktonic populations. The topic of this paper is concerned with an investigation of the longtime behavior of solutions to a biofilm model without growth on domains in R d (d = 1, 2, 3). This analysis is extended(More)
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