Barbara Shykoff

Learn More
Cardiac output (Q), heart rate (HR), blood pressure, and oxygen consumption (VO2) were measured repeatedly both at rest and at two levels of exercise in six subjects during microgravity exposure. Exercise was at 30 and 60% of the workload producing the individual's maximal VO2 in 1 G. Three of the subjects were on a 9-day flight, Spacelab Life Sciences-1,(More)
In the present study, we evaluated the effect of a nonevaluative social support intervention (pet ownership) on blood pressure response to mental stress before and during ACE inhibitor therapy. Forty-eight hypertensive individuals participated in an experiment at home and in the physician's office. Participants were randomized to an experimental group with(More)
  • B E Shykoff
  • Undersea & hyperbaric medicine : journal of the…
  • 2008
To detect cumulative effects of and check required recovery times between underwater exposures to 130-140 kPa oxygen, we assessed pulmonary oxygen toxicity after resting dives for four and six hours on two, five, and six or ten days, and three hours twice on each of two days. Despite a slight downward trend in diffusing capacity, four-hour resting dives(More)
  • B E Shykoff
  • Undersea & hyperbaric medicine : journal of the…
  • 2008
Pulmonary effects of prolonged mild intermittent underwater cycle ergometer exercise were assessed after single and repeated four-hour dives to 12 feet. With air, five daily dives (surface interval [SI], 20 hours), and with 100% oxygen, single dives, five daily dives, and afternoon-morning dives (SI, 15 hours) were conducted. Air divers had no symptoms or(More)
  • B E Shykoff
  • Undersea & hyperbaric medicine : journal of the…
  • 2005
Elevated inspired oxygen partial pressures (PO2) may cause pulmonary oxygen toxicity (PO2T). However, normal variability and water immersion also cause pulmonary function (PF) changes. In 21 subjects, we measured the variability of flow-volume parameters and diffusing capacity for carbon monoxide (DLCO) for six weeks without diving. In 24 divers, we(More)
Foreign and soluble gas rebreathing methods are attractive for determining cardiac output (Q(c)) because they incur less risk than traditional invasive methods such as direct Fick and thermodilution. We compared simultaneously obtained Q(c) measurements during rest and exercise to assess the accuracy and precision of several rebreathing methods. Q(c)(More)
The physiological responses to water immersion (WI) are known; however, the responses to stress following WI are poorly characterized. Ten healthy men were exposed to three physiological stressors before and after a 6-h resting WI (32-33°C): 1) a 2-min cold pressor test, 2) a static handgrip test to fatigue at 40% of maximum strength followed by(More)
We examined the hypothesis that respiratory sinus arrhythmia (RSA) is primarily a central phenomenon and thus that RSA is directly correlated with respiratory controller output. RSA was measured in nine anesthetized dogs, first during spontaneous breathing (SB) and then during constant flow ventilation (CFV), a technique whereby phasic chest wall movements(More)
The relationship between total air flow and normal breath sounds recorded at 2 sites on the chest was investigated. Sounds were measured during rhythmic breathing, during flow rate tracking, and during flow rate tracking against an external resistance by subjects seated and in the left lateral decubitus position. The sound amplitude during inspiration(More)
Reversal by heparin of norepinephrine-induced constriction of normal hand veins was studied. Venous size was measured using a linear variable differential transformer (LVDT) during infusions of saline, norepinephrine, insulin and norepinephrine, and graded doses of heparin with norepinephrine. Heparin reduced the venoconstrictive effects of norepinephrine(More)