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The human KOC gene which is highly expressed in cancer shows typical structural features of an RNA binding protein. We analyzed the temporal and spatial expression pattern of KOC in mouse embryos at different gestational ages. The expression of KOC seems to be ubiquitous at early stages. During advanced gestation highest KOC expression occurs in the gut,(More)
Xenopus FoxD3 (XFD-6) is an intron-less gene initially expressed within the Spemann organizer and later in premigratory neural crest cells. Based upon sequence and expression pattern comparisons, it represents the Xenopus orthologue to zebrafish fkd6, chicken CWH-3 and mammalian HFH-2 (genesis). Early expression of FoxD3 is activated by the Wnt-pathway and(More)
xFoxJ1 and xFoxK1, two novel members of the fork head/winged helix family of transcription factors in Xenopus, have been identified by sequence homology to their mammalian orthologues. We here report the complete amino acid sequences of xFoxJ1, its pseudo-allelic version xFoxJ1', and of xFoxK1, the latter also comprising a fork-head-associated (FHA) domain.(More)
We here describe the sequences and expression patterns of three new Fox (fork head box) transcription factors in Xenopus laevis embryos. xlFoxI2, another member of subclass I, is maternally transcribed. Zygotic transcripts are first detected during neurulation and become localised to the dorsal part of epibranchial placodes. xlFoxM1 like xlFoxP1 are the(More)
We have investigated the sequence and expression pattern of the Xenopus laevis FoxD2 gene, a member of the fork head/winged helix multigene family. The derived protein sequence is most closely related to FoxD2 factors known from other species. Maternal FoxD2 transcripts are degraded during early cleavage stages. Zygotic transcription is activated after the(More)
We report on the temporal and spatial expression pattern of two novel genes of the Xenopus fork head/winged helix family, xFoxB2 and xFoxI1c. xFoxB2 is activated at the late blastula stage and first expressed within the dorsolateral ectoderm except for the organiser territory. During gastrulation, xFoxB2 is found in two ectodermal stripes adjacent to the(More)
Although health care reform efforts are laudably directed at promoting quality and efficiency, added bureaucracy may have the unintended consequence of constraining physicians' creativity. This has the potential to undermine clinicians' freedom to reframe their thinking in response to unfolding biological knowledge, a defining feature of academic medicine.(More)
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