Barbara Ramage

Learn More
BACKGROUND It has been speculated that the hormonal cycle may be correlated with higher incidence of ACL injury in female athletes, but results have been very contradictory. HYPOTHESIS Knee joint loads are influenced by knee joint laxity (KJL) during the menstrual cycle. STUDY DESIGN Controlled laboratory study. METHODS Serum samples and KJL were(More)
AIM The attention and inhibition problems found in children with attention-deficit-hyperactivity disorder (ADHD) are also common in children with fetal alcohol spectrum disorders (FASDs). Attempts to distinguish ADHD from FASDs in terms of these deficits are rare and were pursued in this study. METHOD A total of 116 children (47 with ADHD, 31 males, 16(More)
BACKGROUND An increase in knee laxity during the menstrual cycle may increase the risk of anterior cruciate ligament injury. OBJECTIVE To investigate whether changing knee laxity during the menstrual cycle correlates with changing knee joint loads in a cutting manoeuvre. DESIGN Cross-sectional study. SETTING Laboratory testing. PARTICIPANTS 25(More)
There is an ongoing debate regarding the diagnostic overlap between Attention Deficit Hyperactivity Disorder (ADHD) and Fetal Alcohol Spectrum Disorder (FASD). Differential diagnosis is important because of treatment implications. Children aged 7-10years (47 ADHD, 30 FASD, 39 controls) participated. The Movement Assessment Battery for Children (M-ABC) and(More)
BACKGROUND Duchenne muscular dystrophy is an X-linked recessive muscular dystrophy. Clinical management primarily involves rehabilitation strategies aimed at preserving functional mobility as long as possible. Side-alternating vibration therapy is a rehabilitation intervention that has shown promise in a number of different neuromuscular disorders, and has(More)
Pompe disease (lysosomal acid alpha-glucosidase deficiency) in adolescents and adults presents primarily with muscle weakness. Bone weakness is an under-recognized finding in patients with Pompe disease, but there is emerging evidence that loss of muscle function and mobility can lead to loss of mineral content and a higher risk of fracture. In addition to(More)
Metabolic diseases that lead to neuromuscular, bone, and joint involvement can reduce ambulation and quality of life. Using jumping mechanography, we developed a novel assessment, peak jump power (PJP), and related this to ambulatory ability in patients either having a known or suspected underlying rare disease. From adults and children, we recruited 88(More)
Side-alternating vibration training (SAVT) was used for 15 weeks in a patient with Late-onset Pompe disease who had never used enzyme replacement or chaperone therapy. Prior to the use of SAVT, the patient had experienced declining muscle performance and her 6-minute walk distance decreased from 210 to 155 metres in 6 months. After SAVT, her 6-minute walk(More)
Muscular dystrophy refers to a group of genetic diseases associated with progressive muscle weakness and atrophy. Duchenne Muscular Dystrophy (DMD) is a particularly severe and fatal form of this disease, affecting 1 in 3500 live born males [1]. It is caused by mutations in the dystrophin gene leading to a loss of dystrophin [2]. This results in progressive(More)
Background: Side alternating vibration training (SAVT) is a mechanical oscillation using a vibrating platform that simulates exercise. We hypothesized that patients with mitochondrial myopathies, who experience muscle weakness, may see an improvement in muscle power with SAVT. Methods: Patients with mitochondrial disease started either a treatment (SAVT) or(More)
  • 1