Barbara Murphy

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  • Hiromitsu Hatakeyama, Haixia Cheng, Pamela Wirth, Ashley Counsell, Samuel R. Marcrom, Carey Burton Wood +10 others
  • 2010
BACKGROUND We hypothesized that chronic inhibition of epidermal growth factor receptor (EGFR) by cetuximab, a monoclonal anti-EGFR antibody, induces up-regulation of its ligands resulting in resistance and that microRNAs (miRs) play an important role in the ligand regulation in head and neck squamous cell carcinoma (HNSCC). METHODOLOGY/PRINCIPAL FINDINGS(More)
Living-kidney donation has become increasingly widespread, yet there has been little critical analysis of existing studies of long-term medical outcomes in living donors. This review analyzes issues in study design that affect the quality of the evidence and summarizes possible risk factors in living donors. Virtually all studies of long-term outcomes in(More)
  • Jed J Jacobson, Joel B Epstein, Frederick C Eichmiller, Teresa B Gibson, Ginger S Carls, Emily Vogtmann +2 others
  • 2012
BACKGROUND Head and neck cancers are of particular interest to health care providers, their patients, and those paying for health care services, because they have a high morbidity, they are extremely expensive to treat, and of the survivors only 48% return to work. Consequently the economic burden of oral cavity, oral pharyngeal, and salivary gland cancer(More)
OBJECTIVE The complement system contributes to autoimmune injury, but its involvement in promoting the development of autoimmune diabetes is unknown. In this study, our goal was to ascertain the role of complement C3 in autoimmune diabetes. RESEARCH DESIGN AND METHODS Susceptibility to diabetes development after multiple low-dose streptozotocin treatment(More)
Hepatitis C virus (HCV) infection is the leading cause of liver transplantation (LT) in Western countries. Polymorphism in the IL28B gene region has a major impact on the natural history and response to antiviral treatment in HCV. We investigated whether IL28B polymorphism was associated with graft survival in patients with or without HCV undergoing LT.(More)
In addition to HLA genetic incompatibility, non-HLA difference between donor and recipients of transplantation leading to allograft rejection are now becoming evident. We aimed to create a unique genome-wide platform to facilitate genomic research studies in transplant-related studies. We designed a genome-wide genotyping tool based on the most recent human(More)
— Clinical studies confirm that mental illnesses such as autism, Obsessive Compulsive Disorder (OCD), etc. show behavioral abnormalities even at very young ages; the early diagnosis of which can help steer effective treatments. Most often, the behavior of such at-risk children deviate in very subtle ways from that of a normal child; correct diagnosis of(More)
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