Barbara Mariotti

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IL-10 is a potent anti-inflammatory molecule that, in phagocytes, negatively targets cytokine expression at transcriptional and posttranscriptional levels. Posttranscriptional checkpoints also represent the specific target of a recently discovered, evolutionary conserved class of small silencing RNAs known as "microRNAs" (miRNAs), which display the peculiar(More)
Dryocosmus kuriphilus Yasumatsu, an invasive gall wasp originating from Asia, is the latest serious pest attacking Castanea sativa Mill. in Europe; the negative effects on fruit and wood production are considerable. The most effective defense strategy is biological control, but parasitoid effectiveness requires at least 6–10 years to reduce damage to(More)
Venetoclax (ABT-199) is a small-molecule selective oral inhibitor of the antiapoptotic protein Bcl-2 that promotes programmed cell death of chronic lymphocytic leukemia (CLL) cells regulating the release of proapoptotic factors, such as Smac/Diablo, apoptosis-inducing factor (AIF) and cytochrome c. In April 2016, the U.S. Food and Drug Administration (FDA)(More)
The use of a pharmacokinetic model characterized by a new theoretical approach of the enzymatic reaction allows to account for ethanol concentration-time curve (after oral administration in man) and to simulate the evolution of free enzyme concentration. The interpretation of the various phases observed during these kinetics (ethanol, free enzyme) and(More)
A new approach to the enzymatic elimination of ethanol in vivo allows us by means of a one-compartment model to take into account all the phases of the ethanol concentration-time curve after oral administration. The Michaelis-Menten equation is an approximation of this model; indeed it constituted the only non-linear approach to the kinetic study of(More)
Over the last 30 years in Italy, a high percentage of tree plantations have failed to achieve the objective of enhancing the quality of forest products, and also restoring/rehabilitating abandoned or degraded agricultural lands. In this study, we evaluated the effects of nursery cultivation in large, novel containers and duration of cultivation on early(More)
Following oral administration of ethanol to ethylic as well as non-ethylic volunteers, the entire time course of plasma acetate concentration has been observed. The curve shows a typical evolution in three phases: (1) a quick ascending phase (2) a steady state characterized by a mean concentration (-C) (3) a first-order decrease, characterized by its(More)
Research regarding parameters suitable for reporting on the activity of enzymatic systems responsible for ethanol metabolism is of obvious interest in medico-legal practice. Blood ethanol concentration-time curves, following oral administration of ethanol, have been developed for ethylic and non-ethylic subjects. This study has confirmed the non-linear(More)
Tree shelters are used in many forestry applications because they often improve survival, may stimulate early growth, and can help to maintain apical dominance. Quercus robur, widely used in multipurpose plantings in Europe, usually grows slowly and loses apical dominance in the early stages after establishment. We examined tree shelter effects on Q. robur(More)