Barbara Marciniec

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During silylation of porous glass with 3-aminopropyltriethoxysilane, the properties of the carrier affected the concentration of bound amino groups, the formation of aminopolysiloxane mono- or multilayer on the surface, and the hydrolytic stability of the layer formed. The influence of the carrier depended on the specific surface area and the size of pores.(More)
Thermal degradation of aqueous and buffered solutions of perazine, prochlorperazine, trifluoperazine, thioproperazine, thiethylperazine and butaperazine salts was examined by kinetic method using an accelerated testing of pharmaceutical preparations. The order, rate constants and activation parameters (Q100, E, delta H not equal to, delta S not equal to,(More)
The effect of ionizing radiation in doses between 20 and 200 kGy on physicochemical properties of fluconazole (alpha-(2,4-diflurophenyl)-alpha-(1H-triazol-1-methyl)-1H-1,2,4-triazole-1-ethanol) in the solid state was examined. A number of qualitative and quantitative methods such as scanning electron microscopy (SEM), nuclear magnetic resonance (NMR),(More)
The effect of ionising irradiation on the antifungal drug clotrimazole has been studied. The compound was subjected to ionisation irradiation in the form of high-energy electron beam (25-800 kGy) from an accelerator. Before and after the irradiation the compound was subjected to the EPR, TLC, HPLC and HPLC-MS analysis. After irradiation with doses 400-800(More)
The effect of ionising radiation, applied in the form of an electron beam, in the doses of 25, 100 and 400 kGy on the physical and chemical properties of thiamphenicol in solid phase has been studied by organoleptic analysis (form, colour, smell, solubility, clarity) and spectroscopic methods (UV, IR, EPR), chromatography (TLC), SEM observations, X-ray(More)
The effect of ionizing radiation on florfenicol (FF), an antibiotic with wide antibacterial properties was investigated to determine whether it can be sterilized using high-energy radiation. FF was irradiated by E-beam radiation to doses of 25-800 kGy, and then changes in the physico-chemical properties were examined using chromatographic methods (TLC and(More)
Chromatographic-spectrophotometric methods for the determination of vitamins K1, K3 and K4 in pharmaceuticals (tablets, dragees, injection solutions) in the presence of decomposition products have been elaborated. The TLC method on Kieselgel HF 254 (Merck) was applied to separation of the active substances from decomposition products, using the following(More)
The aims of our study were to assess the release of cytotoxic nucleoside analogs 5-fluorouracil and 2-chloro-2'-deoxyadenosine from different lactide-glycolide or lactide-caprolactone biodegradable copolymers and the effects of sterilization on this release. The polymers were sterilized either with ethylene oxide at 37 degrees C, or with gamma radiation (15(More)
The effect of temperature and air humidity on the stability of 7 derivatives of 1,4-dihydropyridine (nifedipine, nisoldipine, nitrendipine, nimodipine, nicardipine, felodipine and amlodipine) in solid state has been studied by accelerated testing. Quantitative analysis of the compounds studied was made by UV spectrophotometry, identification of the(More)