Barbara M Schroeder

Learn More
When chronic hyponatremia is rapidly corrected, reaccumulation of brain organic osmolytes is delayed and brain cell shrinkage occurs, leading to the osmotic demyelination syndrome (ODS). We hypothesized that treatment with myoinositol, a major organic osmolyte, could prevent ODS. Severe hyponatremia was induced in adult male rats by administration of(More)
Invadopodia are protrusive structures used by tumor cells for degradation of the extracellular matrix to promote invasion [1]. Invadopodia formation and function are regulated by cytoskeletal-remodeling pathways and the oncogenic kinase Src. The guanine nucleotide exchange factor Vav1, which is an activator of Rho family GTPases, is ectopically expressed in(More)
Lipid droplets (LDs) are lipid storage organelles that in hepatocytes may be catabolized by autophagy for use as an energy source, but the membrane-trafficking machinery regulating such a process is poorly characterized. We hypothesized that the large GTPase dynamin 2 (Dyn2), well known for its involvement in membrane deformation and cellular protein(More)
Ubiquitination of the epidermal growth factor receptor (EGFR) by cbl and its cognate adaptor cbl-interacting protein of 85 kDa (CIN85) is known to play an essential role in directing this receptor to the lysosome for degradation. The mechanisms by which this ubiquitin modification is regulated are not fully defined, nor is it clear where this process(More)
An acute increase in plasma tonicity results in an adaptive increase in brain organic osmolyte content, but this process requires several days to occur. Slow reaccumulation of brain organic osmolytes may contribute to osmotic demyelina-tion. It was investigated whether administration of intravenous myoinositol in rats could speed entry of the osmolyte into(More)
Web conferencing, a technology once available only to companies with larger budgets, is now becoming more mainstream due to advances in technology and fierce market competition. In all educational settings (face-to-face, hybrid, and distance learning), this technology has the potential to engage learners and improve learning. However, how does a school(More)
It will be available in PDF format so that a paper copy can be easily printed out. It may subsequently be issued on paper as well. If it is issued on paper, then copies would be available from:
Special issue on " Blogging as an Educational Technology " Blogging is a collaborative tool widely used by the Internet users. Blogging technology allows users to create knowledge by means of collaborating with others. Communication and collaboration is central to the constructivist theory in education. Constructivist theory states that we create and apply(More)