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Aldehyde dehydrogenase-2 (ALDH2) catalyzes the bioactivation of nitroglycerin (glyceryl trinitrate, GTN) in blood vessels, resulting in vasodilation by nitric oxide (NO) or a related species. Because the mechanism of this reaction is still unclear we determined the three-dimensional structures of wild-type (WT) ALDH2 and of a triple mutant of the protein(More)
Comparisons of climate model hindcasts with independent proxy data are essential for assessing model performance in non-analogue situations. However, standardized palaeoclimate data sets for assessing the spatial pattern of past climatic change across continents are lacking for some of the most dynamic episodes of Earth's recent past. Here we present a new(More)
Background Aldehdyde dehydrogenase-2 (ALDH2) is essential for the detoxification of ethanol in the liver but also catalyzes vas-cular bioactivation of nitroglycerin (glycerol trinitrate, GTN) to its active metabolite nitric oxide (NO), which causes vasodilation through accumulation of cyclic GMP. The clinical use of GTN as a vasodilator is hampered by loss(More)
  • Suraya Afif, Taufiq Alimi, Andiko S H, Wiwiek Awiati, Bhola Bhattarai, Amanda Bradley +21 others
  • 2011
Acknowledgements We would like to thank Helen Moriarty for writing a review of FPIC in REDD+ as a basis for this publication and for guiding the early steps of the process of putting this publication together. We would also like to acknowledge the following organizations who participated in developing this publication: Asian Disclaimer All views and errors(More)
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