Learn More
OBJECTIVE To examine the global prevalence and major risk factors for diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) among people with diabetes. RESEARCH DESIGN AND METHODS A pooled analysis using individual participant data from population-based studies around the world was performed. A systematic literature review was(More)
Let y i ; i = 1; ; n be independent observations with the density of y i of the form h(y i ; f i) = expy i f i ?b(f i)+c(y i)], where b and c are given functions and b is twice continuously diierentiable and bounded away from 0. Let f i = f(t(i)), where t = (t 1 ; ; t d) 2 T (1) T (d) = T , the T () are measureable spaces of rather general form, and f is an(More)
We propose the randomized Generalized Approximate Cross Validation (ranGACV) method for choosing multiple smoothing parameters in penalized likelihood estimates for Bernoulli data. The method is intended for application with penalized likelihood smoothing spline ANOVA models. In addition we propose a class of approximate numerical methods for solving the(More)
Tinnitus (ringing or buzzing in the ear or head) can range from barely noticeable to debilitating. Although a few studies have estimated the prevalence of this condition in adult populations, we know of no population-based estimates of incidence. As part of a population-based study of hearing loss in adults aged 48 to 92 years at baseline in Beaver Dam,(More)
The LASSO-Patternsearch algorithm is proposed to efficiently identify patterns of multiple dichotomous risk factors for outcomes of interest in demographic and genomic studies. The patterns considered are those that arise naturally from the log linear expansion of the multivariate Bernoulli density. The method is designed for the case where there is a(More)
PURPOSE To describe the relationship of retinal arteriolar and venular caliber with cardiovascular risk factors, including inflammatory biomarkers, in a multiethnic population of whites, blacks, Hispanics, and Chinese. METHODS A cross-sectional study comprising 5979 persons aged 45 to 84 years residing in six U.S. communities. Retinal vascular caliber was(More)
PURPOSE To examine prevalence of five age-related eye conditions (age-related cataract, AMD, open-angle glaucoma, diabetic retinopathy [DR], and visual impairment) in the United States. METHODS Review of published scientific articles and unpublished research findings. RESULTS Cataract, AMD, open-angle glaucoma, DR, and visual impairment prevalences are(More)
This paper presents a nonparametric penalized likelihood approach for variable selection and model building, called likelihood basis pursuit (LBP). In the setting of a tensor product reproducing kernel Hilbert space, we decompose the log likelihood into the sum of different functional components such as main effects and interactions, with each component(More)
OBJECTIVES To describe the 15-year incidence of retinal vein occlusion (central retinal vein occlusion and branch retinal vein occlusion) and associated risk factors. METHODS A population-based study where branch retinal vein occlusion and central retinal vein occlusion were detected at baseline (n = 4068, 1988-1990) and three 5-year follow-up(More)
We combine a smoothing spline analysis of variance (SS-ANOVA) model and a log-linear model to build a partly exible model for multivariate Bernoulli data. The joint distribution conditioning on the predictor variables is estimated. The log odds ratio is used to measure the association between outcome variables. A numerical scheme based on the block one-step(More)