Barbara Jeanine Hunnicutt

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The thalamus relays sensori-motor information to the cortex and is an integral part of cortical executive functions. The precise distribution of thalamic projections to the cortex is poorly characterized, particularly in mouse. We employed a systematic, high-throughput viral approach to visualize thalamocortical axons with high sensitivity. We then(More)
Familial Dysautonomia (FD; Hereditary Sensory Autonomic Neuropathy; HSAN III) manifests from a failure in development of the peripheral sensory and autonomic nervous systems. The disease results from a point mutation in the IKBKAP gene, which encodes the IKAP protein, whose function is still unresolved in the developing nervous system. Since the neurons(More)
Rett syndrome is a neurological disorder caused by loss of function mutations in the gene that encodes the DNA binding protein methyl-CpG-binding protein 2 (Mecp2). A prominent feature of the syndrome is disturbances in respiration characterized by frequent apnea and an irregular interbreath cycle. 8-Hydroxy-2-dipropylaminotetralin has been shown to(More)
The striatum integrates excitatory inputs from the cortex and the thalamus to control diverse functions. Although the striatum is thought to consist of sensorimotor, associative and limbic domains, their precise demarcations and whether additional functional subdivisions exist remain unclear. How striatal inputs are differentially segregated into each(More)
During amniote embryogenesis the nervous and vascular systems interact in a process that significantly affects the respective morphogenesis of each network by forming a "neurovascular" link. The importance of neurovascular cross-talk in the central nervous system has recently come into focus with the growing awareness that these two systems interact(More)
Understanding and modelling the human speech understanding process requires knowledge i n several domains, from auditory analysis of speech to higher linguistic processes. Integrating this knowledge into a coherent model is not the scope of this paper. Rather we want to present some projects that may add to the understanding of some components that(More)
A neural circuit is a network in which brain regions or individual neurons are the nodes and axonal connections are represented by directed edges. Edges can encode many variables but minimally designate the type of neurotransmitter, which determines whether a cell will excite, inhibit or modulate its targets. We recommend limiting this encoding to line caps(More)
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