Barbara Jakubowska

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OBJECTIVE This randomized, 2-year, double-blind, placebo-controlled, crossover study evaluated cladribine for relapsing forms of multiple sclerosis. DESIGN PATIENTS (n = 84) received seven 5-day courses of subcutaneous cladribine at 5 mg/day (group A) or placebo (group B) in year 1; treatment was reversed in year 2. RESULTS Cladribine was well(More)
We report the results of blood morphology monitoring of 11 remitting-relapsing multiple sclerosis patients who received repeated treatments with cladribine (2-chlorodeoxyadenosine). The drug was given once, daily, subcutaneously (5 mg) or orally (10 mg) for 5 consecutive days, as 6 monthly courses followed by one or two additional courses at 3 or 6 month(More)
PURPOSE The evaluate the frequency of radiation of the optic neuropathy (RON) and its influence on visual acuity in patients with choroidal melanoma treated by brachytherapy. MATERIAL AND METHODS We analyzed 583 patients with choroidal melanoma, treated with ruthenium (106Ru) or iodine (125I) plaques in Ophthalmology Department of Jagiellonian University,(More)
BACKGROUND For majority of Polish people potatoes are indispensable component of daily diet. Boiled or steamed potatoes are considered as food meeting the requirements of right nourishment. They are a source of nutrient components, however, potatoes may contain undesirable compounds. OBJECTIVE The aim of this work was evaluation of dry matter and some(More)
PURPOSE Analysis of type and frequency of complications after brachytherapy 1125 between 1-12 months after treatment and during the following controls. MATERIALS AND METHODS 147 persons (76 men and 71 women) aged 23-86 years (mean 57 years), were treated in our clinic in 1998-2001. In 43% of the cases the thickness of the tumor was more than 8 mm and in(More)
There are few reports of Mg in MS and none dealing with Mg content in erythrocytes. Mg concentration was determined in serum and in erythrocytes with the help of a BIOTROL Magnesium Calmagite colorimetric method (average sensitivity: 0.194 A per mmol/I) and a Hitachi autoanalyzer in 24 MS patients (7 men and 17 women, age 29-60; 37 years on average with the(More)
PURPOSE To report the routs of extraocular extension of uveal melanoma. MATERIAL AND METHODS A retrospective study of 170 enucleated eyes with uveal melanoma and deep intrascleral tumor invasion and/or nodular extrascleral extension. RESULTS The routes of passages by sclera were natural channels: ciliary arteries, ciliary nerves, optic nerve, vortex(More)
Cladribine (2-chloro-2"-deoxyadenosine, 2CdA), a selectively hymphocytotoxic compound, was reported to halt disease progression in chronic progressive MS when dose 0.087-0.1 mg/Kg/day was given in week-long iv infusions repeated monthly. 4-6 times [Sipe et al., Lancet 1994, 344:9], but considerable and possibly dangerous hematologic toxicity was observed(More)