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Menopause drastically increases the risk of osteoporosis. Aside from drug therapy, lifestyle and nutritional factors play an important role in the maintenance of skeletal health. Our recent findings suggest that dried plums, a rich source of phenolic and flavonoid compounds, are highly effective in modulating bone mass in an ovarian hormone-deficient rat(More)
Dried plums and their polyphenols have been shown to suppress bone resorption by downregulating receptor activator NF-kappaB ligand (RANKL). Due to the anti-inflammatory and antioxidant properties of these compounds, this study was designed to investigate whether dried plum polyphenols exert additional, more direct effects on osteoclasts and their(More)
OBJECTIVE We previously reported the efficacy of dried plum (Prunus domestica L.) in preventing ovariectomy-induced bone loss in a rat model of osteoporosis and improving bone biomarkers in postmenopausal women. The present study evaluated whether dried plum was able to restore bone mass in osteopenic ovariectomized rats. DESIGN Ninety-day-old(More)
Cinnamon ( ròu guì) has in vitro insulin potentiating activity, and proanthocyanidins from cinnamon prevent in vitro formation of advanced glycation end products. Some human studies were equivocal, but several have shown beneficial effects of cinnamon supplementation on circulating glucose, lipids, and/or insulin. This placebo-controlled double-blind trial(More)
OBJECTIVE To examine household food insecurity and hunger in Sidama Zone, one of the most populous zones in southern Ethiopia. DESIGN Cross-sectional survey administered individually by trained interviewers. Food insecurity was calculated with both the Household Food Insecurity Access Scale (HFIAS) and the Household Hunger Scale (HHS), developed by the(More)
An experiment was performed to determine whether boron deprivation would adversely affect vertebra (trabecular) bone microarchitecture, and whether any adverse effect would be modified by dietary fatty acid composition. Female rats were fed diets containing 0.1mg (9 micromol) boron/kg in a factorial arrangement with variables of supplemental boron at 0(More)
Rats fed an iron-deficient diet develop decreased bone mass and increased fragility. This study documents that rats fed two minerals likely to be low in American diets, calcium and iron, had dramatic changes in bone density and morphometry. Weanling male Long-Evans rats were fed a diet that was either deficient in iron (5-8 mg/kg or 89-143 micro mol/kg(More)
The question of whether iron deficiency has direct adverse effects on vertebral trabecular bone and long bones was answered by this study. Four groups of female weanling rats were fed for 5 wk diets that were 1) control; 2) calcium restricted, 1.0 g Ca/kg diet; 3) iron deficient, <8 mg Fe/kg diet; or 4) control, pair-fed to the iron-deficient group. Whole(More)
Our previous study demonstrated that green tea polyphenols (GTP) benefit bone health in middle-aged female rats without (sham, SH) and with ovariectomy (OVX), because of GTP's antioxidant capacity. The current study further evaluates whether GTP can restore bone micro-structure in both gonad-intact and gonadal-hormone-deficient middle-aged female rats. A(More)
Chromium (Cr) potentiates the effects of insulin and a role for insulin in ascorbic acid transport has been reported. Therefore, the effects of Cr and ascorbate depletion on tissue ascorbic acid and 14C distribution and excretion after a 14C ascorbate dose were investigated in guinea pigs. As utilization of dietary Cr is affected by interaction with other(More)