Barbara H. Miller

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A coinfection assay was developed to examine Mycobacterium tuberculosis genes suspected to be involved in resistance to killing by human macrophages. THP-1 macrophages were infected with a mixture of equal numbers of recombinant Mycobacterium smegmatis LR222 bacteria expressing an M. tuberculosis gene and wild-type M. smegmatis LR222 bacteria expressing the(More)
BACKGROUND The ability of Mycobacterium tuberculosis to survive and replicate in macrophages is crucial for the mycobacterium's ability to infect the host and cause tuberculosis. To identify Mycobacterium tuberculosis genes involved in survival in macrophages, a library of non-pathogenic Mycobacterium smegmatis bacteria, each carrying an individual(More)
In 1985 Mark Spinrad and Curt Abraham published; "<i>The Wild West Lifecycle (WILI)</i>" [1] which, although written with a slightly irreverent tongue-in-cheek style, introduced a significant metaphor for the software engineering lifecycle. In this paper we will discuss briefly the importance of software metaphors in general, and then revisit and expand the(More)
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