Barbara Eberhardt

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Weight-loss interventions generally improve lipid profiles and reduce cardiovascular disease risk, but effects are variable and may depend on genetic factors. We performed a genetic association analysis of data from 2,993 participants in the Diabetes Prevention Program to test the hypotheses that a genetic risk score (GRS) based on deleterious alleles at 32(More)
Associations of functional status (as measured with the Karnofsky Index), depressive symptoms (as assessed with the Beck Depression Inventory), and sociodemographic characteristics with health-related quality of life (HrQoL; measured with the EORTC Quality of Life Questionnaire QLQ-C30) were assessed in 170 recently diagnosed cancer patients. A better(More)
INTRODUCTION Almost all patients treated with opioids suffer from constipation. Numerous laxatives are used to overcome the problem, but none has yet been found to yield favourable results in all patients. Several studies have attempted to reverse opioid-induced constipation by the use of oral naloxone. Experiments carried out in rats showed that(More)
Purpose: Side effects of chemotherapy on cognitive functions in older patients have rarely been investigated. Addressing this lack of research, the present study evaluated cognitive functions in older cancer patients. Methods: A total of 130 younger (n=59; age<60) and older (n=71; age≥60) cancer patients with hematological disease or cancer of the(More)
To address the lack of research in older cancer patients, the present study prospectively evaluated their cognitive functions across the first six months following diagnosis and chemotherapy. A total of 77 younger (n=43, age < 60) and older (n=34, age ≥ 60) cancer patients with hematological disease or cancer of the intestinal tract took part in the study.(More)
Hintergrund: Häufigste Nebenwirkung einer Therapie chronischer Schmerzen mit Opioiden ist eine Obstipation. Sie beruht größtenteils auf einer Bindung der Opiode an Rezeptoren im Magen-Darmtrakt, aus der sie durch oral verabfolgtes Naloxon verdrängt werden können, ohne daß die analgetische Wirkung wegen der hohen präsystemischen Elimination des Naloxon(More)
INTRODUCTION The aim of this study was to assess the relationship between gender role orientation and the prevalence of chronic pain. METHOD The individual gender role orientation in a sample of 45 chronic pain patients (ICD 10 diagnosis, F 45.4) was compared to gender role orientation in a matched, pain-free control group. Gender role orientation was(More)
The influence of continuous arteriovenous hemofiltration on the pharmacokinetics of azlocillin was examined in eight anuric intensive care patients, each of whom received a short infusion of 5.0 g azlocillin. Azlocillin concentrations in blood were measured simultaneously in the afferent and efferent loops of the amicon Dia 20 hemofilter and in the(More)
To study the sequential growth patterns of hematogenous cerebral metastatic tumors, syngenetic RG<SUB>2</SUB> glioma cells were injected into the right common carotid artery of 61 adult CDF rats.<BR> Electron microscopic study 1 hr and 24 hrs after injection revealed arrested tumor cells in the capillaries, some with faint glial filaments in their(More)
Gibt es einen Zusammenhang zwischen verschiedenen Facetten der Geschlechtsrollenorientierung und chronischem Schmerz? Die Geschlechtsrollenorientierung wurde über Fragebogenskalen zu geschlechtsstereotypen Eigenschaften (GEPAQ) und zu maskulinen und femininen Geschlechtsrollennormen (MRNS, FRNS) erfasst. Verglichen wurden männliche und weibliche Patienten(More)