Barbara Breen

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Airway hyper-responsiveness (AHR), a hallmark of asthma, is a highly complex phenomenon characterised by multiple processes manifesting over a large range of length and time scales. Multiscale computational models have been derived to embody the experimental understanding of AHR. While current models differ in their derivation, a common assumption is that(More)
To estimate the influence of parenchymal heterogeneities on airway-parenchymal interdependence, we considered a circular airway embedded within elastic parenchyma modeled as (1) a hexagonal spring network, (2) a triangular spring network, or (3) a continuum. The deformation in the parenchyma due to active airway contraction was simulated using the finite(More)
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