Barbara Barrett

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For people at risk of depressive relapse, mindfulness-based cognitive therapy (MBCT) has an additive benefit to usual care (H. F. Coelho, P. H. Canter, & E. Ernst, 2007). This study asked if, among patients with recurrent depression who are treated with antidepressant medication (ADM), MBCT is comparable to treatment with maintenance ADM (m-ADM) in (a)(More)
BACKGROUND Results of small trials suggest that early interventions for social communication are effective for the treatment of autism in children. We therefore investigated the efficacy of such an intervention in a larger trial. METHODS Children with core autism (aged 2 years to 4 years and 11 months) were randomly assigned in a one-to-one ratio to a(More)
BACKGROUND Alcohol misuse is highly prevalent among people attending emergency departments, but the effect of intervention by staff working in these departments is unclear. We investigated the effect of screening and referral of patients found to be misusing alcohol while attending an emergency department. METHODS We undertook a single-blind pragmatic(More)
BACKGROUND The CRIMSON (CRisis plan IMpact: Subjective and Objective coercion and eNgagement) study is an individual level, randomised controlled trial that compared the effectiveness of Joint Crisis Plans (JCPs) with treatment as usual for people with severe mental illness. The JCP is a negotiated statement by a patient of treatment preferences for any(More)
We present the cost and cost-effectiveness of referral to an alcohol health worker (AHW) and information only control in alcohol misusing patients. The study was a pragmatic randomised controlled trial conducted from April 2001 to March 2003 in an accident and emergency department (AED) in a general hospital in London, England. A total of 599 adults(More)
BACKGROUND Treatment guidelines identify few adequately powered trials to guide recommendations for anorexia nervosa. AIMS To evaluate the effectiveness of three readily available National Health Service treatments for adolescents (aged 12-18 years) with anorexia nervosa. METHOD Multicentre randomised controlled trial of 167 young people comparing(More)
OBJECTIVES To determine if, in the short term, depressed adolescents attending routine NHS Child and Adolescent Mental Health Services (CAMHS), and receiving ongoing active clinical care, treatment with selective serotonin reuptake inhibitors (SSRIs) plus cognitive behaviour therapy (CBT) compared with SSRI alone, results in better healthcare outcomes. (More)
This text was written by : Thomas C. Baghai2, David S. Baldwin4, Barbara Barrett5, Pierre Baumann15, Kareem Ghalib16, Guy Goodwin8, Heinz Grunze2,3, Martin Knapp5, Brian E. Leonard9, John C. Markowitz17, Frank Padberg2, Roger Pinder12 and Norman Sartorius1. Substantial contributions to some of the chapters were made by Ursula Brand6, Max Fink18, Toshiaki(More)
Autism spectrum disorders (ASD) are associated with a substantial economic burden, but there is little evidence of the costs in the early years; the period in which children are increasingly likely to be diagnosed. We describe the services used by 152 children aged 24-60 months with autism, report family out-of-pocket expenses and productivity losses, and(More)
OBJECTIVE To determine whether a combination of a selective serotonin reuptake inhibitor (SSRIs) and cognitive behaviour therapy (CBT) together with clinical care is more effective in the short term than an SSRI and clinical care alone in adolescents with moderate to severe major depression. DESIGN Pragmatic randomised controlled superiority trial. (More)