Barbara A Sigler

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The use of antibiotic prophylaxis in head and neck surgery is controversial. Most surgeons agree that when surgery requires entry into the aerodigestive tract through the skin the wound is by definition contaminated and antibiotic prophylaxis is indicated as it is in other contaminated wounds. There is no general agreement as to which antibiotic or(More)
Fourteen patients with recurrent squamous cell carcinoma of the head and neck (SCCHN) were treated with 10 x 10(6) U of nonrecombinant interferon alpha (IFN) intramuscularly (IM) daily for 3 days every 28 days. There were 11 men and 3 women, with ages ranging from 48 to 74 years. Patients had previously been treated with surgery (9 patients), radiotherapy(More)
Sixteen patients were monitored for vestibular ototoxicity while receiving cisplatin in dosages of 180 mg/M2. The incidence of preexisting vestibular functional abnormalities (31%) was higher than the incidence of ototoxicity (18%). Although the number of patients was not large enough for meaningful statistical comparison, the incidence of vestibular(More)
Cefazolin and moxalactam were compared in a prospective randomized double-blind trial of 118 patients undergoing oncologic head and neck surgery. Both antibiotics were given 2 g every four hours for four doses. Five infections were encountered in the cefazolin group (8.5%) and two infections in the moxalactam group (3.4%); this difference was not(More)
Controversy remains regarding the use of prophylactic antibiotic therapy in contaminated head and neck surgery. In an attempt to clarify this issue, a prospective double-blind randomized study has been undertaken in patients who were to undergo major contaminated (skin to mucosa) oncologic surgery. The drug combination gentamicin plus clindamycin was(More)
Extracapsular spread (ECS) of lymph node metastases is believed to be an indicator of poor prognosis. In general, it has been thought that ECS was limited to large "fixed" nodes. To test the validity of the assumption that nodes less than 3 cm in diameter do not have ECS, the specimens from 177 radical neck dissections were reviewed retrospectively with(More)
A prospective clinical trial was developed to evaluate efficacy, toxicity, and patient compliance to adjuvant chemotherapy following surgery and postoperative radiation therapy in patients with squamous-cell carcinoma of the head and neck with extracapsular spread of tumor in cervical metastases. Following postoperative radiation therapy, 18 courses of(More)
A major goal of any surgical program for patients with tumors is to cure their cancer. Patients requiring total glossectomy usually are seen initially with far-advanced disease, often after failure of other treatment modalities. As a result, they may be suffering from constant pain as well impairment of speech and deglutition. The prognosis is poor, and(More)
Therapy for early carcinoma of the floor of the mouth is difficult because of the tendency for local invasion of muscle and extension onto the mandible and alveolus. Nearly 100% local control of disease without mandibular complication has been possible with a wide local three-dimensional resection including marginal mandibulectomy with split thickness skin(More)