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Integrative Structure and Functional Anatomy of a Nuclear Pore Complex
TLDR
We determined the structure of the entire 552-protein nuclear pore complex of the yeast Saccharomyces cerevisiae at sub-nanometre precision by satisfying a wide range of data relating to the molecular arrangement of its constituents. Expand
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Simple rules for passive diffusion through the nuclear pore complex
Passive macromolecular diffusion through nuclear pore complexes is thought to decrease dramatically beyond ∼40 kD. Using time-resolved fluorescence microscopy and Brownian dynamics simulations,Expand
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Prediction of transition metal‐binding sites from apo protein structures
Metal ions are crucial for protein function. They participate in enzyme catalysis, play regulatory roles, and help maintain protein structure. Current tools for predicting metal–protein interactionsExpand
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Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation
Structural analysis of the interactions between a receptor and monomeric or dimeric forms of its ligand may aid in drug design. How receptors view monomers versus dimers Chemokines are proteins thatExpand
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Slide-and-exchange mechanism for rapid and selective transport through the nuclear pore complex
Significance The nuclear pore complex (NPC) mediates the trafficking of macromolecules in and out of the nucleus of eukaryotic cells. Here, we characterize how transport factors diffuse rapidlyExpand
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Modeling of proteins and their assemblies with the Integrative Modeling Platform.
To understand the workings of the living cell, we need to characterize protein assemblies that constitute the cell (for example, the ribosome, 26S proteasome, and the nuclear pore complex). AExpand
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A backdoor to the nucleus that runs in the family?
Yoshimura and colleagues show that HEAT proteins that are involved in diverse cellular functions may facilitate their own translocation through the nuclear pore complex, owing to their structuralExpand
Modeling of the yeast Nuclear Pore Complex