Rabies virus (RV) induces encephalomyelitis in humans and animals. However, the pathogenic mechanism of rabies is not fully understood. To investigate the host responses to RV infection, we examined and compared the pathology, particularly the inflammatory responses, and the gene expression profiles in the brains of mice infected with wild-type (wt) virus… (More)
Rotavirus (RV) P is an unique genotype that infects neonates. The mechanism of such age-specific host restriction remains unknown. In this study, we explored host mucosal glycans as a potential age-specific factor for attachment of P RVs. Using in vitro binding assays, we demonstrated that VP8* of a P RV (N155) could bind saliva of infants… (More)
BACKGROUND Breast milk contains anti-rotavirus IgA antibodies and other innate immune factors that inhibit rotavirus replication in vitro. These factors could diminish the immunogenicity of oral rotavirus vaccines, particularly if breastfeeding occurs close to the time of vaccine administration. METHODS Between April 2011 and November 2012, we conducted… (More)
To the Editor: Adenoviruses commonly infect vertebrates, including humans and nonhuman primates (1). Adenoviruses from humans and animals were initially classified by differences in their agglutinating erythrocytes; now, however, they are often classified by sequence and phy-logenetic analyses of their respective genes (2). One simian adenovirus species ,… (More)
The genomic sequence of a rotavirus group H was identified in the intestine of a diarrheal pig in the United States, designated RVH/Pig-wt/USA/MN9.65/2008/GxP[x].
BACKGROUND To effectively analyze the requirements for protection to rotavirus infection, a reliable animal model that reasonably mimics infection and disease in humans is needed. A requirement for an effective animal model is the availability of appropriate rotavirus stocks for challenge. RESULTS A new simian rotavirus, designated YK-1, was isolated from… (More)
INTRODUCTION Live attenuated oral vaccines against rotavirus (RV) have been shown to be less efficacious in children from developing countries. Reasons for this disparity are not fully understood. We assessed the role of maternal factors including breast milk RV-specific IgA, transplacentally acquired infant serum RV-specific IgG and maternal HIV status in… (More)