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IL-1beta has been implicated in inflammatory episode. In view of the inflammatory nature of cancer cachexia, we determined the predictive value of IL-1B-31 T/C, -511 C/T, +3954 C/T and IL-1RN VNTR gene polymorphisms on the occurrence of cachexia associated with locally advanced gastric cancer. The study included 214 patients and 230 healthy volunteers.(More)
The purpose of this study was to determine the predictive value of IL-6-572, -190, and -634 gene polymorphisms on the cachexia susceptibility and survival time of patients with pancreatic cancer. Genotypes were determined using restriction fragment length polymorphism analysis of polymerase chain reaction products. All of the subjects were homozygous to the(More)
BACKGROUND Acute severe pancreatitis (ASP) has an unpredictable course and outcome. Polymorphisms of the tumor necrosis factor (TNF) gene have been related to TNF production and outcome in a variety of inflammatory diseases. We assessed whether TNF gene polymorphism and plasma concentrations of TNF-alpha were related to the occurrence of ASP and septic(More)
When intestinal barrier function is damaged bacterial translocation (BT) can occur. The injury to intestinal barrier function caused by chemotherapy has been investigated in some studies, however, definitive evidence of BT caused by chemotherapy is lacking. The aim of this study was to investigate small intestinal barrier dysfunction and BT and to evaluate(More)
It has been reported that treatment with methotrexate (MTX) induces intestinal bacterial translocation; however, the definitive evidence of intestinal bacterial translocation induced by MTX has been lacking. The aim of this study was to confirm the intestinal bacterial translocation caused by MTX and to evaluate the preventive effect of granulocyte(More)
To solve the non-uniform distribution of stored energy in cold worked materials, a new stored energy distribution model is presented based on mesoscopic mechanism. Then it is introduced into Monte Carlo model to simulate the recrystallization process of pure ferrite steel plate. Through the comparison of simulated results and experimental/theoretical ones,(More)
BACKGROUND Chemotherapy-induced mucosal barrier dysfunction is of clinical interest. However, the assessment of mucosal barrier dysfunction still poses challenges. In this study, we compared several biomarkers with the dual sugar gut permeability test for assessing mucosal barrier dysfunction during chemotherapy. METHODS Forty-two patients with gastric or(More)
Small particles of any kind embedded in organic material, be that toxic nanoparticles, calcifications, or markers down to the atomic level can be identified and analyzed by EDS. Even single atoms as light as S and Si on carbonaceous material are accessible by high-end techniques [1]. We show that the evaluation of the element distribution in combinations of(More)
A modified Voronoi model is established based on the Richard’s method to generate 2D non-equiaxed initial microstructure for Monte Carlo simulation of recrystallization. It is verified to be efficient by comparing the simulated results and the experimental ones. Then the model is introduced to simulate the recrystallization process of pure ferrite steel(More)
OBJECTIVE To investigate the relation of the frequency of TNF2 allele, a TNF-alpha promoter polymorphism, and plasma concentrations of TNF-alpha and soluble tumor necrosis receptor (sTNF-R) to acute severe pancreatitis (ASP) and its severe complication--sepsis. METHODS The DNA samples of peripheral white blood cells of 72 ASP patients, 16 of them being(More)