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Development and characterization of an orodispersible film containing drug nanoparticles.
The result revealed that the ODF containing drug nanoparticles may provide a potential opportunity in transforming drug nanosuspensions into a solid dosage form as well as enhancing the dissolution rate and oral bioavailability of poorly water-soluble drugs. Expand
Hepatoprotective effects of lignans extract from Herpetospermum caudigerum against CCl₄-induced acute liver injury in mice.
The lignans extract of Herpetospermum caudigerum is effective for the prevention of CCl4-induced hepatic damage in mice and HPE may be partially responsible for the pharmacological effect of hepatoprotection. Expand
Development of poly(N-isopropylacrylamide)/alginate copolymer hydrogel-grafted fabrics embedding of berberine nanosuspension for the infected wound treatment
The drug release study demonstrated that hydrogel-grafted fabrics can be used as a sustained drug delivery system of hydrophobic compounds and was found to be a very promising wound healing dressing for the treatment and healing of infected wounds. Expand
Development of a fast dissolving sublingual film containing meloxicam nanocrystals for enhanced dissolution and earlier absorption
Abstract The objective of this work was to prepare and evaluate fast dissolving sublingual films containing meloxicam nanocrystals (MLX-NS-FDSFs). Nanocrystals (NS) were utilized to allow forExpand
Formulation of dried lignans nanosuspension with high redispersibility to enhance stability, dissolution, and oral bioavailability.
The results provide a basis for the development of a drug delivery system for poorly water-soluble ingredients with pH-dependent solubility for anti-hepatitis B virus and hepatoprotective effects. Expand
Self-discriminating fluorescent hybrid nanocrystals: efficient and accurate tracking of translocation via oral delivery.
The results not only validate the idea of using ACQ fluorophores for bioimaging of integral nanocrystals but also support the intestinal absorption of nanocry crystals. Expand
Formulation and optimization of a novel oral fast dissolving film containing drug nanoparticles by Box–Behnken design–response surface methodology
The optimized HPE-NP-OFDF exhibits much faster drug release rates compared to HPE raw material, which indicated that this novel NP-OF DF may provide a potential opportunity for oral delivery of drugs with poor water solubility. Expand
Improve bile duct-targeted drug delivery and therapeutic efficacy for cholangiocarcinoma by cucurbitacin B loaded phospholipid complex modified with berberine hydrochloride.
The results indicated that the CUB-PLC-BER tended to provide a high and prolonged drug concentration to bile duct, and PL played a central role in internalizing CUB into cells to improve the water insoluble drug's permeability, which was of great benefit to enhance the bioavailability of CUB and improve therapeutic efficacy of CC. Expand
Mucoadhesive buccal films containing phospholipid-bile salts-mixed micelles as an effective carrier for Cucurbitacin B delivery
A greater and more extended release of Cu B from nanoscale CCS-films compared to that from a conventional CCS films and oral marketed tablet is revealed and this kind of mucoadhesive buccal film might be an alternative safe route for delivery of CuB with better patient compliance and higher bioavailability for the treatments. Expand
Nanosuspensions based gel as delivery system of nitrofurazone for enhanced dermal bioavailability
Abstract The purpose of this study was to develop stable nitrofurazone nanosuspensions based gel (NTZ nanogel) suitable for topical delivery with a view to increase skin bioavailability. NTZExpand