Banyoon Cheon

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In preparation for fertilization, mammalian oocytes undergo optimization of the mechanisms that regulate calcium homeostasis. Among these changes is the increase in the content of the Ca(2+) stores ([Ca(2+)]ER), a process that requires Ca(2+) influx. Nevertheless, the mechanism(s) that mediates this influx remains obscure, although is known that [Ca(2+)]ER(More)
At the time of fertilization, an increase in the intracellular Ca(2+) concentration ([Ca(2+)](i)) underlies egg activation and initiation of development in all species studied to date. The inositol 1,4,5-trisphosphate receptor (IP(3)R1), which is mostly located in the endoplasmic reticulum (ER) mediates the majority of this Ca(2+) release. The sensitivity(More)
To my family and Caitlin Cotter for their never ending support iv ACKNOWLEDGMENTS First and foremost I would like to thank Dr. Rafael Fissore for granting me the opportunity to join his research lab and allow me to pursue my own research project. Throughout the later years of my time at the University of Massachusetts Amherst he has been an invaluable(More)
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