Bang-mao Wang

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Intestinal dysbiosis is now known to be a complication in a myriad of diseases. Fecal microbiota transplantation (FMT), as a microbiota-target therapy, is arguably very effective for curing Clostridium difficile infection and has good outcomes in other intestinal diseases. New insights have raised an interest in FMT for the management of extra-intestinal(More)
Serotonin (5-HT) and the serotonin transporter (SERT) have earned a tremendous amount of attention regarding the pathogenesis of irritable bowel syndrome (IBS). Considering that enteric 5-HT is responsible for the secretion, motility and perception of the bowel, the involvement of altered enteric 5-HT metabolism in the pathogenesis of IBS has been(More)
AIM To evaluate the hemostatic effect of topical hemocoagulase spray in digestive endoscopy. METHODS Eighty-nine patients who developed oozing bleeding during endoscopic treatment from September 2014 to October 2014 at Center for Digestive Endoscopy, Tianjin Medical University General Hospital were randomly divided into either a study group (n = 39) or a(More)
OBJECTIVE To investigate the clinical characteristics of Chinese patients with Cronkhite-Canada syndrome (CCS). METHODS Relevant data of Chinese CCS patients from 1985 to 2006 were retrieved from Medline and Chinese biomedical database and a meta-analysis was conducted. RESULTS A total of 35 CCS cases had been reported by Chinese hospitals with the(More)
The farnesoid X receptor (FXR) signaling pathway is known to be involved in the metabolism of bile acid, glucose and lipid. In the present study, we demonstrated that 400 µmol/l deoxycholic acid (DCA) stimulation promotes the proliferation of normal human gastric epithelial cells (GES-1). In addition, DCA activated FXR and increased the expression of(More)
BACKGROUND The role of gastro-protecting agents on symptomatic chronic gastritis is unclear. This multicenter, open, randomized trial was designed to compare the comprehensive effects of gefarnate with sucralfate on erosive gastritis with dyspeptic symptoms. METHODS Totally 253 dyspepsia patients confirmed with erosive gastritis were enrolled from six(More)
OBJECTIVE To explore the efficacy of Jinghuaweikang capsules plus triple therapy (LACJ) in treatment of Helicobacter pylori (H. pylori) associated gastritis or duodenal ulcer, compare it with bismuth-containing quadruple therapy (LACB) and standard triple therapy (LAC) and analyze the antibiotic sensitivity of gastric mucosal H. pylori strains from the(More)
Aim:IL-37b has shown anti-cancer activities in addition to its anti-inflammatory properties. In this study, we investigated the effects of IL-37b on breast carcinoma growth in mice and to determine the involvement of T cell activation in the effects.Methods:IL-37b gene was transferred into mouse breast carcinoma cell line 4T1 (4T1-IL37b cells), the(More)
OBJECTIVE To assess the effect of curcumin on deoxycholic acid (DCA) induced cell proliferation in human HT-29 colon cancer cell line and to discuss its underlying anti-cancer mechanisms. METHODS The effect of curcumin on cell proliferation was tested in vitro with MTT assay. RT-PCR was applied to measure cyclooxygenase-2 (COX-2) mRNA transcription.(More)