Bambang Veriansyah

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We report novel pharmaceutical cocrystal of a popular antipyretic drug paracetamol (PCA) with coformer 5-nitroisophhthalic acid (5NIP) to improve its tabletability. The cocrystal (PCA-5NIP at molar ratio of 1:1) was synthesized by solvent evaporation technique using methanol as solvent. The physicochemical properties of cocrystal were characterized by(More)
Oil and xanthorrhizol extraction from Curcuma xanthorrhiza Roxb. rhizome by supercritical carbon dioxide was optimized using Taguchi method. The factors considered were pressure, temperature, carbon dioxide flowrate and time at levels ranging between 10-25 MPa, 35-60 °C, 10-25 g/min and 60-240 min respectively. The highest oil yield (8.0 %) was achieved at(More)
Centella asiatica is a tropical medicinal plant with a long history of therapeutic uses, dermal disorders, venous insufficiency and microangiopathy. The substances of therapeutic interest are the saponin-containing triterpene acids and their sugar esters. Two bioactive components, asiatic acid and asiaticoside, were extracted from Centella asiatica using(More)
Optimum condition for Nigella sativa seeds oil and its bioactive compound, thymoquinone (TQ) using supercritical fluid carbon dioxide extraction (SCFE-CO2), were investigated. The optimization process was performed with Taguchi method and full factorial design (FFD) under the following condition: pressure (150, 200 and 250 bar), temperatures (40, 50 and(More)
Supercritical water oxidation (SCWO) has been drawing much attention due to effectively destroy a large variety of high-risk wastes resulting from munitions demilitarization and complex industrial chemical. An important design consideration in the development of supercritical water oxidation is the information of decomposition rate. In this paper, the(More)
Hydrothermal decomposition of pentachlorophenol (PCP, C6HCl5O), as the probable human carcinogen, was investigated in a tubular reactor under subcritical and supercritical water with sodium hydroxide (NaOH) addition. The experiments were conducted at a temperature range of 300-420 degrees C and a fixed pressure of 25 MPa, with a residence time that ranged(More)
The wastewater from an acrylonitrile manufacturing plant, which is difficult to biodegrade, was decomposed in subcritical and supercritical water. Experiments were carried out at temperature ranging from 299 to 552 degrees C and a pressure of 25 MPa. The initial total organic carbon (TOC) of acrylonitrile wastewater was set from 0.27 to 2.10 mol L(-1) with(More)
A new design of supercritical water oxidation (SCWO) bench-scale reactor has been developed to handle high-risk wastes resulting from munitions demilitarization. The reactor consists of a concentric vertical double wall in which SCWO reaction takes place inside an inner tube (titanium grade 2, non-porous) whereas pressure resistance is ensured by a(More)
We report novel pharmaceutical salts of an anti-hypertensive drug carvedilol (CVD) with pharmaceutically acceptable salt formers, including oxalic acid (OXA), fumaric acid (FUMA), benzoic acid (BZA), and mandelic acid (MDA) via conventional solvent evaporation technique. The pKa difference between CVD and selected acids was greater than 3, thus suggesting(More)
The oxidation rate of pentachlorophenol, [C(6)HCl(5)O] which is used to control termites and as a general herbicide and also as the probable human's carcinogen, was investigated in an isothermal continuous tubular reactor under supercritical water oxidation (SCWO) conditions. The experiments were conducted at a temperature of 400-550 degrees C and a fixed(More)