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  • Judith Ratner, Balu N. Balasubramanian, J Corden, Stephen L. Warren, David B. Bregman
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 1998 (First Publication: 27 February 1998)
  • We have shown previously that UV radiation and other DNA-damaging agents induce the ubiquitination of a portion of the RNA polymerase II large subunit (Pol II LS). In the present study UV irradiationExpand
  • Mark D. Wittman, Joan M. Carboni, +30 authors Dolatrai M. Vyas
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2005 (First Publication: 1 September 2005)
  • Compound 3 (BMS-536924), a novel small-molecule inhibitor of the insulin-like growth factor receptor kinase with equal potency against the insulin receptor is described. The in vitro and in vivoExpand
  • Scott A. Shaw, Balu N. Balasubramanian, +27 authors Phil S Baran
  • Chemistry, Medicine
  • The Journal of organic chemistry
  • 2015 (First Publication: 7 July 2015)
  • Clopidogrel is a prodrug anticoagulant with active metabolites that irreversibly inhibit the platelet surface GPCR P2Y12 and thus inhibit platelet activation. However, gaining an understanding ofExpand
  • Upender Velaparthi, Peiying Liu, +8 authors Dolatrai M. Vyas
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2007 (First Publication: 1 June 2007)
  • A series of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) were examined in which the pendant imidazole moiety was replaced to improveExpand
  • Upender Velaparthi, Mark D. Wittman, +15 authors Dolatrai M. Vyas
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2007 (First Publication: 1 April 2007)
  • The discovery and synthesis of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor 1-receptor (IGF-1R) are presented. Installing amine containing side chains at theExpand