Baldev Kumar Gautam

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Etazolate, a pyrazolopyridine class derivative is selective inhibitor of type 4 phosphodiesterase (PDE4), an enzyme catalyzes the hydrolysis of cyclic nucleotide viz. cAMP & regulates cAMP signal transduction. Enhancing cAMP signal transduction by inhibition of PDE4 is known to be beneficial in depression disorders. Thus, the present study was designed to(More)
Linezolid, an oxazolidinone class derivative is a reversible and nonselective inhibitor of monoamine oxidase (MAO), predominantly for MAO-A type. MAO-A is a key enzyme regulating the catabolism of catecholamine neurotransmitters in the brain. It is well known that the catecholaminergic neuronal systems are associated with depression and inhibition of MAO-A(More)
N-Cyclohexyl-3-methoxyquinoxalin-2-carboxamide (QCM-13), a novel 5-HT3 antagonist identified from a series of compounds with higher pA2 (7.6) and good log P (2.91) value was screened in rodent models of depression such as forced swim test (FST), tail suspension test (TST), interaction studies with standard anti-depressants and confirmatory studies such as(More)
The present study was designed to investigate the putative antidepressant-like activity of 7a, a 5-HT₃ receptor antagonist, (although indirect evidence of 5-HT3 antagonism) with an optimal log P (3.35) and pA₂ value (7.6) greater than ondansetron (pA₂--6.6) using behavioural tests battery of depression. Acute treatment of 7a (0.5-2 mg/kg, i.p.) in mice(More)
OBJECTIVES Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressant drugs. The addition of low dose of 5-hydroxytryptamine type 2A enhances the therapeutic effect of SSRIs. The purpose of the present studies was to test the effects of combined treatment of a low dose of ketanserin (KET) and escitalopram (ESC) on(More)
Recent findings support the hypothesis that CB receptor blockade might be associated with antidepressant and anti-stress effects. In the current study, the anti-depressant-like effects of rimonabant were studied in validated models of depression. Rimonabant (4-8mg/kg, i.p.) significantly decreased the duration of immobility in a dose dependent manner in(More)
Comorbidity commonly refers to the co-occurrence (or dual diagnosis) of two disorders or syndromes in the same patient, regardless of whether the disorders are coincidentally or causally linked. Indeed, illnesses have been classified in discrete diagnostic categories although no sharp discontinuities in symptom distributions are observed across most mental(More)
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