Baixiang Li

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The aim of this study was to assess the effect of the β-amyloid fragment Aβ(25-35) on mitochondrial structure and function and on the expression of proteins associated with the mitochondrial permeability transition pore (MPTP) in rat hippocampal neurons. Ninety clean-grade Sprague-Dawley rats were randomly assigned to six groups (n = 15 per group).(More)
OBJECTIVE To investigate the effect of cell proliferation induced by beta-ionone. METHODS Human mammary cancer cells (MCF-7) were treated with various beta-ionone concentrations (25, 50, 100 and 200 mumol/L), with a negative control. Methods such as curve of cell growth, cellular mitosis, the cell clone formatting and DNA synthesis were employed. (More)
Dibromoacetic acid (DBA) is a haloacetic acid that is present in drinking water as a by-product of chlorinated disinfection. To evaluate its potential adverse health effects, the immunotoxicological effects of DBA on the thymus and spleen of BALB/c mice were investigated. Groups of mice (10 mice per group) were administered DBA at doses of 0, 5, 20, and 50(More)
BACKGROUND Sphingomyelin (SM) hydrolysis generates biologically active products regulating cell growth, differentiation and apoptosis. Dietary SM has been found to inhibit colonic tumorigenesis. Alkaline sphingomyelinase (alk-SMase) is the key enzyme responsible for sphingomyelin digestion in the gut. Whether or not dietary sphingomyelin affects alk-SMase(More)
Paraquat and maneb are identified environmental pollutants. Combined exposure to paraquat and maneb is a latent risk factor for many diseases, particularly those of the central nervous system, including Parkinson's disease and Alzheimer's disease. Hippocampus is the key structure in memory formation and babies are more sensitive to environmental stimuli(More)
In this study, the release of mitochondrial proapoptotic intermembrane space proteins induced by exogenous C2-ceramide in human colon carcinoma (HT-29) cell line was investigated. HT-29 cells were treated with 12.5, 25 and 50 μmol/L C2-ceramide in vitro. Flow cytometer was used to detect the mitochondrial membrane potential (ΔΦm). Subcellular fractions were(More)
The herbicide, atrazine (ATR), is used worldwide and its contamination in the environment has resulted in documented human exposure. It has also been shown that ATR results in dopaminergic neurotoxicity, however, few studies have investigated the long-term effects of ATR following in utero exposure. Therefore, we evaluated the effects of ATR exposure in(More)
A series of 2-(2-benzhydrylbenzenamino)pyridine ligands (L1–L13) was synthesized and used as bidentate N^N ligands with nickel halides to afford the corresponding nickel dihalide complexes L(2)Ni(2)Cl(4) C1–C13 and L(2)NiBr(2) D1–D13. All ligands and complexes were characterized by IR and NMR spectroscopy, and by elemental analysis. The molecular structures(More)
Paraoxonase (PON1) is one of the major players in the detoxification of organophosphates (OPs). This study presents our investigation into the effect of OPs on serum PON1 activity and the distribution of common PON1 polymorphisms in Han Chinese workers with repeated high exposure to OP pesticides, and the factors modulating PON1 activity. In all, 400(More)
A series of 2-[1-(4,6-dimethyl-2-benzhydrylphenylimino)ethyl]-6-[1-(arylimino)ethyl]pyridines was synthesized and used to prepare the iron(II) and cobalt(II) chloride complexes thereof. All organic compounds were fully characterized by elemental analysis, IR and NMR ((1)H/(13)C) spectroscopy, whilst the metal complexes were characterized by elemental(More)