Bailey Petersen

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The natural killer (NK) type of aggressive large granular lymphocytic (LGL) leukemia is a fatal illness that pursues a rapid clinical course. There are no effective therapies for this illness, and pathogenetic mechanisms remain undefined. Here we report that the survivin was highly expressed in both aggressive and chronic leukemic NK cells but not in normal(More)
Zinc-finger nucleases (ZFNs) are engineered site-specific DNA cleavage enzymes that may be designed to recognize long target sites and thus cut DNA with high specificity. ZFNs mediate permanent and targeted genetic alteration via induction of a double-strand break at a specific genomic site. Compared to conventional homology-based gene targeting, ZFNs can(More)
Agents with stem cell-toxic potential are frequently used for salvage therapy of Hodgkin's disease (HD) and high-grade non-Hodgkin's lymphoma (NHL). Because many patients with relapsed or refractory lymphoma are candidates for autologous progenitor cell transplantation, possible toxic effects of salvage chemotherapy on progenitor cells must be taken into(More)
Endogenous Damage Associated Molecular Pattern (DAMP) proteins are known as important pro-inflamma-tory factors of the immune system, which are released during cellular stress. Recognition of DAMPs involves the multiligand Receptor for Advanced Glycation End products (RAGE) and Toll-like receptors (TLRs) in sensing not only Pathogen Associated Molecular(More)
Microtubules (MT) and actin filaments of phagocytes exhibit highly dynamic properties. The underlying molecular mechanisms are not entirely known. Their exceptional dynamic cytoskeleton is the prerequisite of many phagocyte related functions like exocytosis, phagocytosis, and in particular migration. Cell dynamic/migration is a highly complex process(More)
The degree of tyrosine-O-sulfation and the ratio between large (gastrin-34 and component I) and small (gastrin-17 and -14) molecular forms of gastrin were studied in extracts of human fetal (n = 14) and adult (n = 9) antrum, duodenum, jejunum and pancreas. Boiled water extracts were applied to gel- and ion-exchange chromatography before and after treatment(More)
After a meal the serum concentrations of the N-terminal tridecapeptide-like fragment of gastrin-17, (1-13)G-17, increased markedly in patients with active duodenal ulcer, but less so in healthy subjects. Consequently the synthetic (1-13)G-17 was infused intravenously in doses that resulted in concentrations similar to those measured in duodenal ulcer(More)
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