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Elm1 kinase activates the spindle position checkpoint kinase Kin4
Elm1 phosphorylates a conserved residue within the Kin4 kinase domain to coordinate spindle position with cell cycle progression.
The cortical protein Lte1 promotes mitotic exit by inhibiting the spindle position checkpoint kinase Kin4
Lte1 directly inhibits Kin4 activity and restricts its binding to the mother spindle pole body, which allows proper mitotic exit of cells with a correctly aligned spindle.
A Memory System of Negative Polarity Cues Prevents Replicative Aging
Cdc42 is a highly conserved master regulator of cell polarity. Here, we investigated the mechanism by which yeast cells never re-establish polarity at cortical sites (cytokinesis remnants [CRMs])Expand
The 14-3-3 protein Bmh1 functions in the spindle position checkpoint by breaking Bfa1 asymmetry at yeast centrosomes
Phosphorylation of Bfa1 by Kin4 creates a docking site on Bfa1 for the 14-3-3 family protein Bmh1, which in turn weakens Bfa1–centrosome association and promotes symmetric Bfa1 localization to engageExpand
Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain.
Midbrain dopaminergic (mDA) neurons modulate various motor and cognitive functions, and their dysfunction or degeneration has been implicated in several psychiatric diseases. Both Sonic HedgehogExpand
WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis
ABSTRACT Ciliogenesis initiates at the mother centriole through a series of events that include membrane docking, displacement of cilia-inhibitory proteins and axoneme elongation. CentriolarExpand
CRISPR-Cas12a-assisted PCR tagging of mammalian genes
Here we describe a simple and time-efficient strategy for endogenous gene tagging in mammalian tissue culture cells. We take advantage of CRISPR-Cas12a-induced double strand breaks and their repairExpand
LRRC45 contributes to early steps of axoneme extension
ABSTRACT Cilia perform essential signalling functions during development and tissue homeostasis. A key event in ciliogenesis occurs when the distal appendages of the mother centriole form a platformExpand
The cortical protein Lte 1 promotes mitotic exit by inhibiting the spindle position checkpoint kinase Kin 4
The unequal distribution of cell fate determinants during asymmetric cell division is a fundamental process that underlies the generation of cell diversity in a variety of multicellular organismsExpand
Elm 1 kinase activates the spindle position checkpoint kinase Kin 4
The Rockefeller University Press $30.00 J. Cell Biol. Vol. 190 No. 6 975–989 www.jcb.org/cgi/doi/10.1083/jcb.201006151 JCB 975 Correspondence to Gislene Pereira: g.pereira@dkfz.de M.I.L. Orrico’sExpand