Bahru Habtemariam

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The Runt domain (RD) is the DNA-binding region of the Runx genes. A related protein, known as core binding factor b (CBFb) also binds to the RD to enhance RD–DNA interaction by 6-to 10-fold. Here, we report results from molecular dynamics (MD) simulations of RD alone, as a dimer in complexes with DNA and CBFb and in a ternary complex with DNA and CBFb.(More)
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