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Range sidelobe artifacts which are associated with pulse compression methods can be reduced with a new method composed of pulse elongation and deconvolution (PED). While pulse compression and PED yield similar signal-to-noise ratio (SNR) improvements, PED inherently minimizes the range sidelobe artifacts. The deconvolution is implemented as a stabilized(More)
MOTIVATION Metagenomic sequencing allows reconstruction of microbial genomes directly from environmental samples. Omega (overlap-graph metagenome assembler) was developed for assembling and scaffolding Illumina sequencing data of microbial communities. RESULTS Omega found overlaps between reads using a prefix/suffix hash table. The overlap graph of reads(More)
De novo genome assembly of next-generation sequencing data is one of the most important current problems in bioinformatics, essential in many biological applications. In spite of significant amount of work in this area, better solutions are still very much needed. We present a new program, SAGE, for de novo genome assembly. As opposed to most assemblers,(More)
The METR technical reports are published as a means to ensure timely dissemination of scholarly and technical work on a non-commercial basis. Copyright and all rights therein are maintained by the authors or by other copyright holders, notwithstanding that they have offered their works here electronically. It is understood that all persons copying this(More)
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